Manuel Llano

TL;DR: Examination of HLA-E antigen distribution indicated that it is detectable on the surface of a wide variety of cell types, consistent with the prediction that the ligand for CD94/NKG2A is expressed ubiquitously.

TL;DR: A novel inhibitory MHC class I receptor of the immunoglobulin-superfamily is characterized, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells, suggesting that diverse leukocyte lineages have adopted recognition of self–MHC class II molecules as a common strategy to control cellular activation during an immune response.

TL;DR: LEDGF is the first example of a cellular protein controlling the location of HIV integration in human cells and it is found that integration was less frequent in transcription units, lessrequent in genes regulated by LEDGF/p75 and more frequent in GC-rich DNA.

TL;DR: Fractionally minute levels of endogenous p75 are sufficient to enable integration and show that cellular factors that engage HIV after entry may elude identification in less intensive knockdowns, showing that p75-integrase interaction may have therapeutic potential.

TL;DR: The results raise the possibility that CD94/NKG2‐mediated recognition of HLA‐E expressed on extravillous cytotrophoblasts plays an important role in maternal‐fetal cellular interactions.