T
Teresa Klinowska
Researcher at AstraZeneca
Publications - 69
Citations - 4616
Teresa Klinowska is an academic researcher from AstraZeneca. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 23, co-authored 61 publications receiving 3733 citations. Previous affiliations of Teresa Klinowska include University of Manchester.
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Journal ArticleDOI
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase
Peter Ballard,Robert Hugh Bradbury,Laurent Francois Andre Hennequin,D. Mark Hickinson,Johnson Paul David,Jason Grant Kettle,Teresa Klinowska,Rémy Morgentin,Donald J. Ogilvie,Annie Olivier +9 more
TL;DR: Optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase and a representative compound 12a inhibited tumour growth in a mouse xenograft model.
Journal ArticleDOI
Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket.
Peter Ballard,Robert Hugh Bradbury,Craig S. Harris,Laurent Francois Andre Hennequin,Mark Hickinson,Johnson Paul David,Jason Grant Kettle,Teresa Klinowska,Andrew G. Leach,Rémy Morgentin,Martin Pass,Donald J. Ogilvie,Annie Olivier,Nicolas Warin,Emma J. Williams +14 more
TL;DR: A series of novel C-5 substituted anilinoquinazolines, selected on the basis of docking experiments and overlays with ATP in the active site of EGFR tyrosine kinase, have been prepared and found to be potent inhibitors.
Journal ArticleDOI
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
James S. Scott,Thomas A. Moss,Amber Balazs,Barlaam Bernard Christophe,Jason Breed,Rodrigo J. Carbajo,Elisabetta Chiarparin,Paul R. J. Davey,Oona Delpuech,Stephen Fawell,David I Fisher,Sladjana Gagrica,Eric Gangl,Tyler Grebe,Ryan Greenwood,Sudhir M. Hande,Holia Hatoum-Mokdad,Kara Herlihy,Samantha Jayne Hughes,Thomas Anthony Hunt,Hoan Huynh,Sophie L. M. Janbon,Tony Johnson,Stefan Kavanagh,Teresa Klinowska,Mandy Lawson,Andrew Lister,Stacey Marden,Dermot F. McGinnity,Christopher J. Morrow,J. Willem M. Nissink,Daniel Hillebrand O'donovan,Bo Peng,Radoslaw Polanski,Darren Stead,Stephen Stokes,Kumar Thakur,Scott Throner,Michael J. Tucker,Jeffrey G. Varnes,Haixia Wang,David Matthew Wilson,Dedong Wu,Ye Wu,Bin Yang,Wenzhan Yang +45 more
TL;DR: This compound was demonstrated to be a highly potent SERD which showed a comparable pharmacological profile to fulvestrant in its ability to degrade ER in both MCF-7 and CAMA-1 cell lines.
Journal ArticleDOI
Inhibitors of epidermal growth factor receptor tyrosine kinase: optimisation of potency and in vivo pharmacokinetics.
Peter Ballard,Robert Hugh Bradbury,Craig S. Harris,Laurent Francois Andre Hennequin,Mark Hickinson,Jason Grant Kettle,Jane Kendrew,Teresa Klinowska,Donald J. Ogilvie,Stuart E. Pearson,Emma J. Williams,Ingrid Wilson +11 more
TL;DR: The structure-activity and structure-property relationships of anilinoquinazoline inhibitors of EGFR were investigated and strategies to lower volume of distribution and shorten half-life through structure and pKa modulation are discussed.
Journal ArticleDOI
Circulating biomarkers and resistance to endocrine therapy in metastatic breast cancers: Correlative results from AZD9496 Oral SERD phase I trial
Costanza Paoletti,Gaia Schiavon,Emily M. Dolce,Elizabeth P. Darga,T. Hedley Carr,Joseph Geradts,Matthias Hoch,Teresa Klinowska,Justin P.O. Lindemann,Gayle Marshall,Shethah Morgan,Parul Patel,Vicky Rowlands,Nitharsan Sathiyayogan,Kimberly Aung,Erika Hamilton,Manish Patel,Anne C Armstrong,Komal Jhaveri,Seock-Ah Im,Nadia Iqbal,Fouziah Butt,Caroline Dive,Elizabeth A. Harrington,J. Carl Barrett,Richard D. Baird,Daniel F. Hayes +26 more
TL;DR: Elevated CTC at baseline was a strong prognostic factor in this cohort and integrating multiple biomarkers in prospective trials may improve outcome prediction and ET resistance mechanisms' identification over a single biomarker.