C
Carol J. Thiele
Researcher at National Institutes of Health
Publications - 153
Citations - 8664
Carol J. Thiele is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Neuroblastoma & Tropomyosin receptor kinase B. The author has an hindex of 50, co-authored 143 publications receiving 8078 citations. Previous affiliations of Carol J. Thiele include University of Pennsylvania.
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Decreased expression of N- myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
TL;DR: It is reported that in the case of RA-induced differentiation of neuroblastoma cell lines, a decreased level of expression is detected within 6 h of treatment and precedes both cell-cycle changes and morphological differentiation.
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MYCN and the epigenome
TL;DR: It is shown that in NB, the PRC2 complex is elevated in undifferentiated NB tumors and functions to suppress a number of tumor suppressor genes, and this role may be altered during tumorigenesis.
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Adrenomedullin expression in human tumor cell lines : its potential role as an autocrine growth factor
Mae Jean Miller,Alfredo Martínez,Edward J. Unsworth,Carol J. Thiele,Terry W. Moody,Theodore H. Elsasser,Frank Cuttitta +6 more
TL;DR: The collective data demonstrate that AM and AM receptor are expressed in numerous human cancer cell lines of diverse origin and constitute a potential autocrine growth mechanism that could drive neoplastic proliferation.
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Glycogen synthase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death
TL;DR: It is demonstrated here that 6‐OHDA evoked endoplasmic reticulum (ER) stress, which was characterized by an up‐regulation in the expression of GRP78 and GADD153 (Chop), cleavage of procaspase‐12, and phosphorylation of eukaryotic initiation factor‐2 a in a human dopaminergic neuronal cell line (SH‐SY5Y) and cultured rat cerebellar granule neurons (CGNs).
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The MYCN oncogene is a direct target of miR-34a.
Jun Stephen Wei,Young K. Song,Steffen Durinck,Qing-Rong Chen,Qing-Rong Chen,Adam Cheuk,Patricia S. Tsang,Quangeng Zhang,Carol J. Thiele,Andrew Slack,Jason M. Shohet,Javed Khan +11 more
TL;DR: One important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma is demonstrated, and it is demonstrated that MYCN is a direct target ofmiR- 34a.