T
Thad Baker
Researcher at Genentech
Publications - 4
Citations - 1733
Thad Baker is an academic researcher from Genentech. The author has contributed to research in topics: B-cell activating factor & B cell. The author has an hindex of 4, co-authored 4 publications receiving 1680 citations.
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Journal ArticleDOI
FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
Ilona Holcomb,Rhona C. Kabakoff,Betty Chan,Thad Baker,Austin L. Gurney,William J. Henzel,Christopher Nelson,Henry B. Lowman,Barbara D. Wright,Nicholas J. Skelton,Gretchen Frantz,Daniel Tumas,Franklin Peale,David L. Shelton,Caroline C. Hébert +14 more
TL;DR: Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine‐rich secreted protein, FIZZ1, which may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonaryinflammatory.
Journal ArticleDOI
Activation and accumulation of B cells in TACI-deficient mice
Minhong Yan,Hua Wang,Betty Chan,Meron Roose-Girma,Sharon Erickson,Thad Baker,Daniel Tumas,Iqbal S. Grewal,Vishva M. Dixit +8 more
TL;DR: TACI may play an unexpected inhibitory role in B cell activation that helps maintain immunological homeostasis in mice that were deficient in TACI.
Journal ArticleDOI
Development of Th1-type immune responses requires the type I cytokine receptor TCCR
Chen Q,Nico Ghilardi,Wang H,Thad Baker,Ming-Hong Xie,Austin L. Gurney,Iqbal S. Grewal,de Sauvage Fj +7 more
TL;DR: The results demonstrate the existence of a new cytokine receptor involved in regulating the adaptive immune response and critical to the generation of a Th1 response.
Journal ArticleDOI
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.
Hua Wang,Scot A. Marsters,Thad Baker,Betty Chan,Wyne P. Lee,Ling Fu,Daniel Tumas,Minhong Yan,Vishva M. Dixit,Avi Ashkenazi,Iqbal S. Grewal +10 more
TL;DR: It is shown here that TACI-Fc blocks the activation of T cells in vitro and inhibits antigen-specific T cell activation and priming in vivo and in a mouse model for rheumatoid arthritis, treatment substantially inhibited inflammation, bone and cartilage destruction and disease development.