Betty Chan

TL;DR: Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine‐rich secreted protein, FIZZ1, which may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonaryinflammatory.

TL;DR: A critical role for BR3 in B cell ontogeny is underscored by data showing that the BR3 gene had been inactivated by a discrete, approximately 4.7 kb gene insertion event that disrupted the 3' end of theBR3 gene in A/WySnJ mice, which lack peripheral B cells.

TL;DR: TACI may play an unexpected inhibitory role in B cell activation that helps maintain immunological homeostasis in mice that were deficient in TACI.

TL;DR: It is shown here that TACI-Fc blocks the activation of T cells in vitro and inhibits antigen-specific T cell activation and priming in vivo and in a mouse model for rheumatoid arthritis, treatment substantially inhibited inflammation, bone and cartilage destruction and disease development.

TL;DR: The therapeutic potential of blocking T-lymphocyte costimulation by CTLA4-IgG as a possible immunosuppressive treatment for patients with allergic asthma is indicated.