Theo J. Moraes

TL;DR: It is shown that RSV interacts with host-cell nucleolin via the viral fusion envelope glycoprotein and binds specifically to nucleolin at the apical cell surface in vitro and RNAi-mediated knockdown of lung nucleolin was associated with a significant reduction in RSV infection in mice, confirming that nucleolin is a functional RSV receptor in vivo.

TL;DR: Providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria, which support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota.

TL;DR: It is shown that after macrophage secretion, MMP-12 is transported into virus-infected cells, and it is suggested that inhibiting extracellular M MP-12 could be a new avenue for the development of antiviral treatments.

TL;DR: The primary function of neutrophils in the innate immune response – to contain and kill invading microbial pathogens – is achieved through a series of rapid and coordinated responses culminating in phagocytosis and intracellular killing of the pathogens.

TL;DR: Although the data support a key role for neutrophil elastase in the pathogenesis of ARDS, further study is needed to fully define the actions of neutrophils, and how these actions affect host functions, before the authors can exploit this knowledge for therapeutic benefit.