M
Ming You
Researcher at Medical College of Wisconsin
Publications - 292
Citations - 14146
Ming You is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 55, co-authored 279 publications receiving 12886 citations. Previous affiliations of Ming You include University of Toledo & University of Toledo Medical Center.
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Journal ArticleDOI
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
Ken Inoki,Hongjiao Ouyang,Tianqing Zhu,Charlotta Lindvall,Yian Wang,Xiaojie Zhang,Qian Yang,Christina N. Bennett,Yuko Harada,Kryn Stankunas,Cun-Yu Wang,Xi He,Ormond A. MacDougald,Ming You,Bart O. Williams,Kun-Liang Guan +15 more
TL;DR: Results show that, in addition to transcriptional activation, Wnt stimulates translation and cell growth by activating the TSC-mTOR pathway, and the sequential phosphorylation of TSC2 by AMPK and GSK3 reveals a molecular mechanism of signal integration in cell growth regulation.
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Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Ramaswamy Govindan,Li Ding,Malachi Griffith,Janakiraman Subramanian,Nathan D. Dees,Krishna L. Kanchi,Christopher G. Maher,Robert S. Fulton,Lucinda Fulton,John W. Wallis,Ken Chen,Jason Walker,Sandra McDonald,Ron Bose,David M. Ornitz,Dong Hai Xiong,Ming You,David J. Dooling,Mark A. Watson,Elaine R. Mardis,Richard K. Wilson +20 more
TL;DR: Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs, including ROS1 and ALK, as well as novel metabolic enzymes.
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Principles for the post-GWAS functional characterization of cancer risk loci
Matthew L. Freedman,Alvaro N.A. Monteiro,Simon A. Gayther,Simon A. Gayther,Gerhard A. Coetzee,Angela Risch,Christoph Plass,Graham Casey,Mariella De Biasi,Christopher S. Carlson,David Duggan,Michael A. James,Pengyuan Liu,Jay W. Tichelaar,Haris G. Vikis,Ming You,Ian G. Mills,Ian G. Mills +17 more
TL;DR: In this article, the authors propose principles for the initial functional characterization of cancer risk loci, with a focus on non-coding variants, and define post-GWAS functional characterization.
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Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse
TL;DR: The data indicate that the strain A mouse lung tumor model is a very sensitive system to detect the ability of chemicals to activate the Ki-ras protooncogene in lung tissue.
Journal ArticleDOI
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
Yan Lu,William J. Lemon,Pengyuan Liu,Yijun Yi,Carl Morrison,Ping Yang,Zhifu Sun,Janos Szoke,William L. Gerald,Mark A. Watson,Ramaswamy Govindan,Ming You +11 more
TL;DR: A gene expression signature consisting of 64 genes that is highly predictive of which stage I lung cancer patients may benefit from more aggressive therapy is identified, useful in predicting survival of stage I NSCLC and might be useful in informing treatment decisions.