H
Haris G. Vikis
Researcher at Washington University in St. Louis
Publications - 39
Citations - 3327
Haris G. Vikis is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 25, co-authored 39 publications receiving 3169 citations. Previous affiliations of Haris G. Vikis include Medical College of Wisconsin & University of Michigan.
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Journal ArticleDOI
Principles for the post-GWAS functional characterization of cancer risk loci
Matthew L. Freedman,Alvaro N.A. Monteiro,Simon A. Gayther,Simon A. Gayther,Gerhard A. Coetzee,Angela Risch,Christoph Plass,Graham Casey,Mariella De Biasi,Christopher S. Carlson,David Duggan,Michael A. James,Pengyuan Liu,Jay W. Tichelaar,Haris G. Vikis,Ming You,Ian G. Mills,Ian G. Mills +17 more
TL;DR: In this article, the authors propose principles for the initial functional characterization of cancer risk loci, with a focus on non-coding variants, and define post-GWAS functional characterization.
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Mechanisms of regulating the Raf kinase family.
TL;DR: This review will summarize recent findings on the regulation of Raf kinase, which involves the integration of other signalling pathways as well as intramolecular interactions, phosphorylation, dephosphorylation and protein-protein interactions.
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Wildtype Kras2 can inhibit lung carcinogenesis in mice.
Zhongqiu Zhang,Yian Wang,Haris G. Vikis,Leisa Johnson,Gongjie Liu,Jie Li,Marshall W. Anderson,Robert C. Sills,Hue-Hua L. Hong,Theodora R. Devereux,Tyler Jacks,Kun-Liang Guan,Ming You +12 more
TL;DR: Data suggest that wildtype Kras2 has tumor suppressor activity and is frequently lost during lung tumor progression, as well as an inverse correlation between the level of wildtypes expression and extracellular signal–regulated kinase (ERK) activity in these cells.
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Activation of FAK and Src are receptor-proximal events required for netrin signaling
Weiquan Li,Jeeyong Lee,Haris G. Vikis,Seung-Hee Lee,Guofa Liu,Jennifer Aurandt,Tang-Long Shen,Eric R. Fearon,Jun-Lin Guan,Min Han,Yi Rao,Kyonsoo Hong,Kun-Liang Guan +12 more
TL;DR: A model in which DCC functions as a kinase-coupled receptor, and FAK and Src act immediately downstream of DCC in netrin signaling is suggested.
Journal ArticleDOI
Regulation of STAT3 by direct binding to the Rac1 GTPase.
Amy Simon,Amy Simon,Haris G. Vikis,Scott Stewart,Barry L. Fanburg,Brent H. Cochran,Kun-Liang Guan +6 more
TL;DR: It is shown that the Rac1 guanosine triphosphatase can bind to and regulate STAT3 activity and that Rac1 may serve as an alternate mechanism for targeting STAT3 to tyrosine kinase signaling complexes.