T
Theresa M. Wardell
Researcher at Newcastle University
Publications - 13
Citations - 965
Theresa M. Wardell is an academic researcher from Newcastle University. The author has contributed to research in topics: Mitochondrial DNA & Heteroplasmy. The author has an hindex of 9, co-authored 13 publications receiving 930 citations.
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Journal ArticleDOI
The epidemiology of pathogenic mitochondrial DNA mutations.
Patrick F. Chinnery,Margaret A. Johnson,Theresa M. Wardell,R. Singh-Kler,C Hayes,D. T. Brown,Robert W. Taylor,Laurence A. Bindoff,Douglass M. Turnbull +8 more
TL;DR: It is demonstrated that pathogenic mtDNA mutations are a common cause of chronic morbidity and have resource implications, particularly for supportive care and genetic counseling.
Journal ArticleDOI
Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR
Langping He,Patrick F. Chinnery,Steve E. Durham,Emma L. Blakely,Theresa M. Wardell,Gillian M. Borthwick,Robert W. Taylor,Douglass M. Turnbull +7 more
TL;DR: An assay to determine the relative amount of deleted mtDNA using real-time fluorescence PCR that detects the vast majority of deleted molecules, thus eliminating the need to develop specific probes and will further the understanding of the role of mtDNA mutations in human disease and ageing.
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Changes in the human mitochondrial genome after treatment of malignant disease
Theresa M. Wardell,Elaine Ferguson,Patrick F. Chinnery,Gillian M. Borthwick,Robert W. Taylor,Graham Jackson,Alan W. Craft,Robert N. Lightowlers,Neil Howell,Douglass M. Turnbull +9 more
TL;DR: It is shown that in patients who have been treated for cancer there is an increased level of mtDNA damage, and samples from patients who had received radiotherapy and chemotherapy for point mutations within the mtDNA control region, and for large-scale deletions were studied.
Journal ArticleDOI
Mitochondrial diabetes: investigation and identification of a novel mutation.
Stephen Lynn,Theresa M. Wardell,Mark A. Johnson,Patrick F. Chinnery,Mark E. Daly,Mark Walker,D.M. Turnbull +6 more
Journal ArticleDOI
Linked oligodeoxynucleotides show binding cooperativity and can selectively impair replication of deleted mitochondrial DNA templates
Robert W. Taylor,Theresa M. Wardell,Bernard A. Connolly,Douglass M. Turnbull,Robert N. Lightowlers +4 more
TL;DR: It is shown that molecules can be designed to bind more tightly to the deleted as compared to the wild-type mtDNA template, consistent with the nucleotide sequence on either side of the linker co-operating to increase binding affinity, and these bridging molecules are capable of sequence-dependent partial inhibition of replication in vitro.