T
Theresa T. Pizarro
Researcher at Case Western Reserve University
Publications - 136
Citations - 10055
Theresa T. Pizarro is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Ileitis & Inflammatory bowel disease. The author has an hindex of 45, co-authored 124 publications receiving 8779 citations. Previous affiliations of Theresa T. Pizarro include University of Virginia & University of Southern California.
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Journal ArticleDOI
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Dimitris L. Kontoyiannis,Manolis Pasparakis,Theresa T. Pizarro,Fabio Cominelli,George Kollias +4 more
TL;DR: Development of two specific pathologies in mutant mice, i.e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies.
Journal Article
IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells
Theresa T. Pizarro,Miette H. Michie,Marcia Bentz,Jan Woraratanadharm,Michael F. Smith,Eugene F. Foley,Christopher A. Moskaluk,Stephen J. Bickston,Fabio Cominelli +8 more
TL;DR: This report is the first describing increased expression of IL-18 in a human Th1-mediated chronic inflammatory disease, and further support the concept that IEC and dendritic cells may possess important immunoregulatory functions in both normal, as well as pathological, mucosal immunity.
Journal Article
Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.
Vincenzo Casini-Raggi,Lori Kam,Yoo Jin T Chong,Claudio Fiocchi,Theresa T. Pizarro,Fabio Cominelli +5 more
TL;DR: The hypothesis that an imbalance between IL-1 andIL-1ra production is of pathogenic importance in chronic inflammatory diseases, including IBD, is supported.
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Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.
Luca Pastorelli,Rekha R. Garg,Sharon B. Hoang,Luisa Spina,Benedetta Mattioli,Melania Scarpa,Claudio Fiocchi,Maurizio Vecchi,Theresa T. Pizarro +8 more
TL;DR: The IL-33/ST2 system plays an important role in IBD and experimental colitis, is modulated by anti-TNF therapy, and may represent a specific biomarker for active UC.
Journal ArticleDOI
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics.
Luca Pastorelli,Luca Pastorelli,Carlo De Salvo,Joseph R. Mercado,Maurizio Vecchi,Theresa T. Pizarro +5 more
TL;DR: Several recently proposed therapeutic approaches to treat human IBD are targeted at enhancing different elements of gut barrier function, further supporting a primary role of the epithelium in the pathogenesis of chronic intestinal inflammation and emphasizing the importance of maintaining a healthy and effective intestinal barrier.