T
Thomas Brzoska
Researcher at University of Münster
Publications - 46
Citations - 2844
Thomas Brzoska is an academic researcher from University of Münster. The author has contributed to research in topics: Inflammation & Proinflammatory cytokine. The author has an hindex of 29, co-authored 46 publications receiving 2716 citations. Previous affiliations of Thomas Brzoska include University of Duisburg-Essen.
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Journal ArticleDOI
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
Sonja Ständer,Corinna Moormann,Mark Schumacher,Jörg Buddenkotte,Metin Artuc,Victoria M. Shpacovitch,Thomas Brzoska,Undine Lippert,Beate M. Henz,Thomas A. Luger,Dieter Metze,Martin Steinhoff +11 more
TL;DR: VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.
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Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.
TL;DR: KdPT, a derivative of KPV corresponding to amino acids 193-195 of IL-1beta, is also emerging as a tripeptide with antiinflammatory effects, suitable for the future treatment of immune-mediated inflammatory skin and bowel disease, fibrosis, allergic and inflammatory lung disease, ocular inflammation, and arthritis.
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New Insights into the Functions of α‐MSH and Related Peptides in the Immune System
TL;DR: A substantial body of evidence that the tridecapeptide alpha-melanocyte-stimulating hormone (alpha-MSH) functions as a mediator of immunity and inflammation is presented in this article.
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Evidence for Expression of Melanocortin-1 Receptor in Human Sebocytes In Vitro and In Situ
Markus Böhm,Meinhard Schiller,Sonja Ständer,Holger Seltmann,Zhuo Li,Thomas Brzoska,Dieter Metze,Helgi B. Schiöth,Anna Skottner,Kristina Seiffert,Christos C. Zouboulis,Thomas A. Luger +11 more
TL;DR: It is shown here that the melanocortin-1 receptor is expressed in vitro and in situ in human sebocytes, and may act as a modulator of inflammatory responses in the pilosebaceous unit by modulating interleukin-8 secretion.
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Agonists of Proteinase-Activated Receptor 2 Induce Cytokine Release and Activation of Nuclear Transcription Factor κB in Human Dermal Microvascular Endothelial Cells
Victoria M. Shpacovitch,Thomas Brzoska,Jörg Buddenkotte,Christoph Stroh,Christian P. Sommerhoff,John C. Ansel,Klaus Schulze-Osthoff,Nigel W. Bunnett,Thomas A. Luger,Martin Steinhoff +9 more
TL;DR: Proteinase-activated receptor 2 may play an important role in cutaneous inflammation by mediating inflammatory responses on dermal microvascular endothelial cells and activation of nuclear transcription factor kappaB.