T
Thomas C. Luke
Researcher at Naval Medical Research Center
Publications - 39
Citations - 3190
Thomas C. Luke is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 17, co-authored 35 publications receiving 2860 citations. Previous affiliations of Thomas C. Luke include Silver Spring Networks & Henry M. Jackson Foundation for the Advancement of Military Medicine.
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Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines
Theron Gilliland,Yanan Liu,Rong Li,Matthew D. Dunn,Emily L. Cottle,Yutaka Terada,Zachary Ryckman,Maria Alcorn,Shauna N. Vasilatos,Jeneveve D. Lundy,Deanna Larson,Hua Wu,Thomas C. Luke,Christoph L Bausch,Kristi A Egland,Eddie Sullivan,Zhongde Wang,William B. Klimstra +17 more
TL;DR: In this paper, the authors used fully human polyclonal human IgG (SAB-185), derived from hyperimmunization of transchromosomic bovines with DNA plasmids encoding the SARS-CoV-2 Wa-1 strain S protein or purified ectodomain of S protein.
Journal ArticleDOI
A dengue DNA vaccine formulated with Vaxfectin® is well tolerated, and elicits strong neutralizing antibody responses to all four dengue serotypes in New Zealand white rabbits
Kanakatte Raviprakash,Thomas C. Luke,John A. Doukas,Janine R. Danko,Kevin R. Porter,Timothy Burgess,Tadeusz J. Kochel +6 more
TL;DR: The formulated vaccine and the adjuvant were tested for safety and/or immunogenicity in New Zealand white rabbits using a repeat dose toxicology study and were found to be well tolerated by the animals.
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Dengue virus photo-inactivated in presence of 1,5-iodonaphthylazide (INA) or AMT, a psoralen compound (4′-aminomethyl-trioxsalen) is highly immunogenic in mice
Kanakatte Raviprakash,Peifang Sun,Yossef Raviv,Thomas C. Luke,Nicholas J. Martin,Tadeusz J. Kochel +5 more
TL;DR: Two novel methods of dengue virus inactivation using iodonaphthyl azide and aminomethyl trioxsalen were compared with traditional virus in activation by formaldehyde, and only mice vaccinated with AMT inactivated virus mounted T cell responses similar to live, uninactivated virus.
Journal ArticleDOI
Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants.
Zhuoming Liu,Hua Wu,Kristi A Egland,Theron C. Gilliland,Matthew D. Dunn,Thomas C. Luke,Eddie Sullivan,William B. Klimstra,Christoph L Bausch,Sean P. J. Whelan +9 more
TL;DR: In this article, a polyclonal, fully human, anti-SARS-CoV-2 immunoglobulin produced in transchromosomic bovines was hyperimmunized with two doses of plasmid DNA encoding the SARS CoV 2 Wuhan strain S gene, followed by repeated immunization with spike protein purified from insect cells.
Journal ArticleDOI
Full-Genome Sequence of Human Betacoronavirus 2c Jordan-N3/2012 after Serial Passage in Mammalian Cells
Kenneth G. Frey,C. L. Redden,Kimberly A. Bishop-Lilly,Reed F. Johnson,Lisa E. Hensley,Kanakatte Raviprakash,Thomas C. Luke,Tad Kochel,Vishwesh P. Mokashi,Gabriel Defang +9 more
TL;DR: The full genome sequence of the Jordan-N3/2012 strain after serial passage in two distinct mammalian cell lines exhibits noteworthy stability, which may inform the development of vaccines and therapeutics used to treat infection with this virus.