H
Hua Wu
Researcher at Washington University in St. Louis
Publications - 39
Citations - 2234
Hua Wu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Sperm & Antibody. The author has an hindex of 23, co-authored 39 publications receiving 2029 citations. Previous affiliations of Hua Wu include University of Massachusetts Amherst.
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Journal ArticleDOI
Production of cattle lacking prion protein.
Jiirgen A. Richt,Poothappillai Kasinathan,Amir N. Hamir,Joaquín Castilla,Thillai Sathiyaseelan,Francisco Vargas,Janaki Sathiyaseelan,Hua Wu,Hiroaki Matsushita,Julie Koster,Shinichiro Kato,Isao Ishida,Claudio Soto,James M. Robl,Yoshimi Kuroiwa +14 more
TL;DR: The generation and characterization of PrPC-deficient cattle produced by a sequential gene-targeting system are reported and at over 20 months of age the cattle are clinically, physiologically, histopathologically, immunologically and reproductively normal.
Journal ArticleDOI
Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation.
TL;DR: It is suggested that persistent stimulation of the phosphoinositide pathway in mouse eggs by the sperm during fertilization or by injection of SF leads to down-regulation of the IP3R-1.
Journal ArticleDOI
Injection of a porcine sperm factor triggers calcium oscillations in mouse oocytes and bovine eggs
TL;DR: The hypothesis that a factor from the sperm is capable, upon release into the oocyte's cytosol, of initiating oscillations supported, and the observed patterns were species‐specific.
Journal ArticleDOI
Antigen-specific human polyclonal antibodies from hyperimmunized cattle
Yoshimi Kuroiwa,Poothappillai Kasinathan,Thillainayagen Sathiyaseelan,Jin-an Jiao,Hiroaki Matsushita,Janaki Sathiyaseelan,Hua Wu,Jenny Mellquist,Melissa Hammitt,Julie Koster,Satoru Kamoda,Katsumi Tachibana,Isao Ishida,James M. Robl +13 more
TL;DR: A Tc bovine system that produces large yields of antigen-specific human polyclonal antibodies and a hIgG-mediated humoral immune response comprising a high proportion of antigen-specific hIGG is reported.
Journal ArticleDOI
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.
Thomas C. Luke,Hua Wu,Jincun Zhao,Jincun Zhao,Rudragouda Channappanavar,Christopher M. Coleman,Jin An Jiao,Hiroaki Matsushita,Ye Liu,Elena Postnikova,Britini L. Ork,Gregory M. Glenn,David Flyer,Gabriel Defang,Kanakatte Raviprakash,Tadeusz J. Kochel,Jonathan T. Wang,Wensheng Nie,Gale Smith,Lisa E. Hensley,Gene G. Olinger,Jens H. Kuhn,Michael R. Holbrook,Reed F. Johnson,Stanley Perlman,Eddie Sullivan,Matthew B. Frieman +26 more
TL;DR: Tc bovines, combined with the ability to quickly produce Tc hIgG and develop in vitro assays and animal model(s), potentially offer a platform to rapidly produce a therapeutic to prevent and/ or treat MERS-CoV infection and/or other emerging infectious diseases.