Z
Zhuoming Liu
Researcher at Washington University in St. Louis
Publications - 55
Citations - 6152
Zhuoming Liu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 23, co-authored 55 publications receiving 2809 citations. Previous affiliations of Zhuoming Liu include University of Tokyo & Broad Institute.
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Journal ArticleDOI
Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.
Allison J. Greaney,Allison J. Greaney,Tyler N. Starr,Pavlo Gilchuk,Seth J. Zost,Elad Binshtein,Andrea N. Loes,Andrea N. Loes,Sarah K Hilton,John Huddleston,Rachel Eguia,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Sean P. J. Whelan,Robert H. Carnahan,Robert H. Carnahan,James E. Crowe,James E. Crowe,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +27 more
TL;DR: A deep mutational scanning method is described to map how all amino-acid mutations in the RBD affect antibody binding, and this method is applied to 10 human monoclonal antibodies to enable rational design of antibody therapeutics and assessment of the antigenic consequences of viral evolution.
Journal ArticleDOI
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
Ruochen Zang,Ruochen Zang,Maria Florencia Gomez Castro,Broc T. McCune,Qiru Zeng,Paul W. Rothlauf,Paul W. Rothlauf,Naomi M. Sonnek,Zhuoming Liu,Kevin Brulois,Kevin Brulois,Xin Wang,Harry B. Greenberg,Harry B. Greenberg,Michael S. Diamond,Matthew A. Ciorba,Sean P. J. Whelan,Siyuan Ding +17 more
TL;DR: In this article, the authors reported productive infection of SARS-CoV-2 in ACE2+ mature enterocytes in human small intestinal enteroids, which may contribute to local and systemic illness and overall disease progression.
Journal ArticleDOI
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2.
Matthew McCallum,Anna De Marco,Florian A. Lempp,M. Alejandra Tortorici,M. Alejandra Tortorici,Dora Pinto,Alexandra C. Walls,Martina Beltramello,Alexander Chen,Zhuoming Liu,Fabrizia Zatta,Samantha K Zepeda,Julia di Iulio,John E. Bowen,Martin Montiel-Ruiz,Jiayi Zhou,Laura E. Rosen,Siro Bianchi,Barbara Guarino,Chiara Silacci Fregni,Rana Abdelnabi,Shi Yan Caroline Foo,Paul W. Rothlauf,Louis Marie Bloyet,Fabio Benigni,Elisabetta Cameroni,Johan Neyts,Agostino Riva,Gyorgy Snell,Amalio Telenti,Sean P. J. Whelan,Herbert W. Virgin,Davide Corti,Matteo Samuele Pizzuto,David Veesler +34 more
TL;DR: In this article, 41 human monoclonal antibodies derived from memory B cells were used to identify the SARS-CoV-2 S N-terminal domain (NTD).
Journal ArticleDOI
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.
Zhuoming Liu,Laura A. VanBlargan,Louis Marie Bloyet,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Spencer Stumpf,Haiyan Zhao,John M. Errico,Elitza S. Theel,Mariel J. Liebeskind,Brynn Alford,William Buchser,Ali H. Ellebedy,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +16 more
TL;DR: In this article, a VSV-eGFP-SARS-CoV-2-S chimeric virus was exposed to 19 neutralizing monoclonal antibodies (mAbs) against the receptor-binding domain (RBD) and generated 50 different escape mutants.
Journal ArticleDOI
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2
James Brett Case,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Zhuoming Liu,Haiyan Zhao,Arthur S. Kim,Louis Marie Bloyet,Qiru Zeng,Stephen Tahan,Lindsay Droit,Ma. Xenia G. Ilagan,Michael A Tartell,Michael A Tartell,Gaya K. Amarasinghe,Jeffrey P. Henderson,Shane Miersch,Mart Ustav,Sachdev S. Sidhu,Herbert W. Virgin,David Wang,Siyuan Ding,Davide Corti,Elitza S. Theel,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +26 more
TL;DR: Two neutralizing activities of various antibodies and ACE2-Fc soluble decoy protein in both assays revealed a high degree of concordance, which will help define correlates of protection for antibody-based countermeasures and vaccines against SARS-CoV-2.