E
Eddie Sullivan
Researcher at Washington University in St. Louis
Publications - 75
Citations - 2084
Eddie Sullivan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 23, co-authored 72 publications receiving 1902 citations. Previous affiliations of Eddie Sullivan include Westport Innovations.
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Journal ArticleDOI
Cloned transchromosomic calves producing human immunoglobulin
Yoshimi Kuroiwa,Poothappillai Kasinathan,Yoon J. Choi,Rizwan Naeem,Kazuma Tomizuka,Eddie Sullivan,Jason G. Knott,Anae Duteau,Richard A. Goldsby,Barbara A. Osborne,Isao Ishida,James M. Robl +11 more
TL;DR: A human artificial chromosome vector containing the entire unrearranged sequences of the human immunoglobulin heavy-chain (H) and lambda (λ) light-chain loci was introduced into bovine primary fetal fibroblasts using a microcell-mediated chromosome transfer (MMCT) approach.
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Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle.
Yoshimi Kuroiwa,Poothappillai Kasinathan,Hiroaki Matsushita,Janaki Sathiyaselan,Eddie Sullivan,Makoto Kakitani,Kazuma Tomizuka,Isao Ishida,James M. Robl +8 more
TL;DR: A sequential gene targeting system for primary fibroblast cells is reported that alleviates the need for germline transmission for complex genetic modifications and should be broadly applicable to gene functional analysis and to biomedical and agricultural applications.
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Histone H1 kinase activity in bovine oocytes following calcium stimulation.
TL;DR: It is shown that increasing the number of Ca2+ stimulations delayed the onset and reduced the extent of H1 kinase reactivation in the first parthenogenetic cell cycle.
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Electrically induced calcium elevation, activation, and parthenogenetic development of bovine oocytes.
TL;DR: The results indicate that the level of Ca2+ stimulation can be regulated by incubation conditions prior to the pulse and, to some extent, by field strength and pulse duration.
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Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.
Thomas C. Luke,Hua Wu,Jincun Zhao,Jincun Zhao,Rudragouda Channappanavar,Christopher M. Coleman,Jin An Jiao,Hiroaki Matsushita,Ye Liu,Elena Postnikova,Britini L. Ork,Gregory M. Glenn,David Flyer,Gabriel Defang,Kanakatte Raviprakash,Tadeusz J. Kochel,Jonathan T. Wang,Wensheng Nie,Gale Smith,Lisa E. Hensley,Gene G. Olinger,Jens H. Kuhn,Michael R. Holbrook,Reed F. Johnson,Stanley Perlman,Eddie Sullivan,Matthew B. Frieman +26 more
TL;DR: Tc bovines, combined with the ability to quickly produce Tc hIgG and develop in vitro assays and animal model(s), potentially offer a platform to rapidly produce a therapeutic to prevent and/ or treat MERS-CoV infection and/or other emerging infectious diseases.