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Thomas D. Barber
Researcher at Johns Hopkins University
Publications - 5
Citations - 3000
Thomas D. Barber is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mutation frequency & Protein subunit. The author has an hindex of 5, co-authored 5 publications receiving 2983 citations. Previous affiliations of Thomas D. Barber include Eli Lilly and Company.
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Genomic landscapes of human breast and colorectal cancers
Laura D. Wood,Williams D. Parsons,Sian Jones,Jimmy Lin,Tobias Sjöblom,Thomas D. Barber,Giovanni Parmigiani,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: Based on analysis of exons representing 20,857 transcripts from 18,191 genes, the authors concluded that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency.
Journal ArticleDOI
TEM8 Interacts with the Cleaved C5 Domain of Collagen α3(VI)
Akash Nanda,Eleanor B. Carson-Walter,Steven Seaman,Thomas D. Barber,Jason Stampfl,Sujay Singh,Bert Vogelstein,Kenneth W. Kinzler,Brad St. Croix +8 more
TL;DR: It is demonstrated that TEM8 protein is preferentially expressed in endothelial cells of neoplastic tissue and the results suggest that the T EM8/C5 interaction may play an important biological role in tumor angiogenesis.
Journal ArticleDOI
Whole-Genome Sequencing Of Asian Lung Cancers: Second-Hand Smoke Unlikely To Be Responsible for Higher Incidence Of Lung Cancer Among Asian Never-Smokers
Vidhya G. Krishnan,Philip J. Ebert,Jason C. Ting,Elaine Lim,Swee-Seong Wong,Audrey S.M. Teo,Yong G. Yue,Hui-Hoon Chua,Xiwen Ma,Gary S.L. Loh,Yuhao Lin,Joanna H.J. Tan,Kun Yu,Shenli Zhang,Christoph Reinhard,Daniel Shao-Weng Tan,Brock A. Peters,Stephen E Lincoln,Dennis G. Ballinger,Jason M. Laramie,Geoffrey B. Nilsen,Thomas D. Barber,Patrick Tan,Axel M. Hillmer,Pauline C. Ng +24 more
TL;DR: The high incidence of lung cancer in Asian never-smokers seems unlikely to be due to second-hand smoke or other carcinogens that cause oxidative DNA damage, implying that routine EGFR testing is warranted in the Asian population regardless of smoking status.
Journal ArticleDOI
Mutations in Two Short Noncoding Mononucleotide Repeats in Most Microsatellite-Unstable Colorectal Cancers
Tuija Hienonen,Heli Sammalkorpi,Susa Enholm,Pia Alhopuro,Thomas D. Barber,Rainer Lehtonen,Nina N. Nupponen,Heli J. Lehtonen,Reijo Salovaara,Jukka-Pekka Mecklin,Heikki Järvinen,Riitta Koistinen,Diego Arango,Virpi Launonen,Bert Vogelstein,Auli Karhu,Lauri A. Aaltonen +16 more
TL;DR: It is indicated that high mutation frequencies, similar or higher than those observed in proposed and approved target genes, can be detected in repeat tracts of MSI tumors without any apparent selection pressure.
Journal ArticleDOI
Response to Comments on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"
Giovanni Parmigiani,Jimmy Lin,Simina M. Boca,Tobias Sjöblom,Siân Jones,Laura D. Wood,D. Williams Parsons,Thomas D. Barber,Thomas D. Barber,Phillip Buckhaults,Sanford D. Markowitz,Ben Ho Park,Kurtis E. Bachman,Nickolas Papadopoulos,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculescu +16 more
TL;DR: A variety of statistical methods used to analyze mutational data published in Sjöblom et al. support the conclusion that a large number of genes are mutated at rates greater than the passenger mutation rate.