Jason M. Laramie

TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.

TL;DR: The polyglutamine tract in huntingtin appears to regulate mitochondrial ADP-phosphorylation in a Ca2+-dependent process that fulfills the genetic criteria for the HD trigger of pathogenesis, and it thereby determines a fundamental biological parameter--cellular energy status, which may contribute to the exquisite vulnerability of striatal neurons in HD.

TL;DR: This perspective summarizes insights, recent developments, and recommendations for infusing actionable computational evidence into clinical development and health care from academy, biotechnology industry, nonprofit foundations, regulators, and technology corporations.

TL;DR: Using single nucleotide polymorphisms from a 100K genome-wide scan, this work examines the associations of common polymorphisms with phenotypic variation in this community-based cohort and provides a full-disclosure, web-based resource of results for future replication studies.

TL;DR: The findings suggest that the method of RNA isolation from whole blood is a critical variable in the design of clinical studies using microarray analyses, as well as examining their reproducibility, variance, and signal-to-noise ratios.