T
Thomas F. Schulz
Researcher at Hannover Medical School
Publications - 354
Citations - 18612
Thomas F. Schulz is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Kaposi's sarcoma-associated herpesvirus & Kaposi's sarcoma. The author has an hindex of 72, co-authored 350 publications receiving 17537 citations. Previous affiliations of Thomas F. Schulz include University of Parma & Infineon Technologies.
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Journal ArticleDOI
Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma
Denise Whitby,Chris Boshoff,T. Hatzioannou,R A Weiss,Thomas F. Schulz,Mark R Howard,N S Brink,Richard S. Tedder,M Tenant-Flowers,Andrew Copas,F.E.A Suggett,D. Aldam,A.S. Denton,Robert F. Miller,Ian Weller +14 more
TL;DR: It is reported that KSHV was detectable in peripheral blood mononuclear cells of 24/46 of KS patients, but in none of 134 blood donors or 26 HIV-uninfected hospital controls, providing a potential explanation for the apparently limited spread of this virus.
Journal ArticleDOI
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells.
C Boshoff,Thomas F. Schulz,M M Kennedy,A. K. Graham,Cyril Fisher,A Thomas,James O'd. McGee,R A Weiss,John J. O'Leary +8 more
TL;DR: Using PCR in situ hybridization (PCR-ISH) it is shown that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells.
Journal ArticleDOI
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
Guy Simpson,Thomas F. Schulz,Denise Whitby,Pamela M. Cook,Chris Boshoff,Lucille Rainbow,Mark R Howard,Shou-Jiang Gao,Roy A. Bohenzky,Peter Simmonds,C. A. Lee,A de Ruiter,Angelos Hatzakis,Richard S. Tedder,Ian Weller,R A Weiss,Patrick S. Moore +16 more
TL;DR: The distribution of antibodies to both a capsid-related recombinant protein and latent antigen of KSHV strongly supports the view that infection with this virus is largely confined to individuals with, or at increased risk for, KS.
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The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen.
Lucille Rainbow,Georgina M. Platt,Guy Simpson,R Sarid,Shou-Jiang Gao,H Stoiber,C S Herrington,Patrick S. Moore,Thomas F. Schulz +8 more
TL;DR: It is demonstrated that orf73 encodes the 222- to 234-kDa LNA, is a component of LANA, and is expressed in KS tumor cells, as well as the characteristic speckled nuclear immunofluorescence pattern ofLANA on Western blots.
Journal ArticleDOI
HIV-associated lymphomas and gamma-herpesviruses
TL;DR: The current knowledge about HIV-associated lymphomas can be summarized in the following key points: lymphomas specifically occurring in patients with HIV infection are closely linked to other viral diseases; AIDS lymphomas fall in a spectrum of B-cell differentiation where those associated with EBV or KSHV commonly exhibit plasmablastic differentiation.