T
Thomas Flatt
Researcher at University of Fribourg
Publications - 114
Citations - 7370
Thomas Flatt is an academic researcher from University of Fribourg. The author has contributed to research in topics: Population & Adaptation. The author has an hindex of 42, co-authored 107 publications receiving 6212 citations. Previous affiliations of Thomas Flatt include Brown University & University of Basel.
Papers
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Journal ArticleDOI
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
TL;DR: It is argued that studying “hormonal pleiotropy” offers intriguing insights into phenotypic integration and the mechanisms underlying life history evolution, and illustrated the role of JH as a key mediator of life history trade‐offs.
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The evolutionary genetics of canalization.
TL;DR: This paper reviews what has been learned about canalization since Waddington and explains why different forms of selection can favor canalization, and in terms of genetic redundancy, modularity, and emergent properties of gene networks and biochemical pathways, it is concluded that there are still serious problems with unambiguously demonstrating canalization.
Book
Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs
Thomas Flatt,Andreas Heyland +1 more
TL;DR: This chapter discussesMechanisms into life history evolution, growth, development, and maturity, and the role of technology in development and trade-offs.
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Size and shape: the developmental regulation of static allometry in insects.
Alexander W. Shingleton,W. Anthony Frankino,Thomas Flatt,H. Frederik Nijhout,Douglas J. Emlen +4 more
TL;DR: Recent advances in the fields of growth regulation and endocrinology are reviewed and used to construct a developmental model of static allometry expression in insects that serves as the foundation for a research program that will result in a deeper understanding of the relationship between growth and form.
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Drosophila germ-line modulation of insulin signaling and lifespan.
Thomas Flatt,Kyung-Jin Min,Kyung-Jin Min,Cecilia D’Alterio,Eugenia Villa-Cuesta,John Cumbers,Ruth Lehmann,D. Leanne Jones,Marc Tatar +8 more
TL;DR: It is reported that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling, suggesting that signals from the gonad regulate lifespan andmodulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved.