J
John Cumbers
Researcher at Brown University
Publications - 16
Citations - 1348
John Cumbers is an academic researcher from Brown University. The author has contributed to research in topics: Space exploration & BioBrick. The author has an hindex of 8, co-authored 16 publications receiving 1207 citations. Previous affiliations of John Cumbers include Ames Research Center & University of California, Santa Cruz.
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Journal ArticleDOI
Measuring the activity of BioBrick promoters using an in vivo reference standard
Jason R Kelly,Adam J. Rubin,Joseph H. Davis,Caroline M. Ajo-Franklin,John Cumbers,Michael J. Czar,Kim de Mora,Aaron L. Glieberman,Dileep D. Monie,Drew Endy,Drew Endy +10 more
TL;DR: In this paper, the relative activity measurement based on an in-vivo reference standard has been proposed to support the measurement of promoter activities across many laboratories, and a measurement kit has been developed so that researchers might more easily adopt RPU as a standard unit for reporting promoter activity.
Measuring the activity of BioBrick promoters using an in vivo reference standard
Jason R Kelly,Adam J. Rubin,Joseph H. Davis,Caroline M. Ajo-Franklin,John Cumbers,Michael J. Czar,Kim de Mora,Aaron L. Glieberman,Dileep D. Monie,Drew Endy,Drew Endy +10 more
TL;DR: Improvements in relative activity measurements based on an in vivoreference standard enables improved measurement of promoter activity given variation in measurement conditions and instruments.
Journal ArticleDOI
Drosophila germ-line modulation of insulin signaling and lifespan.
Thomas Flatt,Kyung-Jin Min,Kyung-Jin Min,Cecilia D’Alterio,Eugenia Villa-Cuesta,John Cumbers,Ruth Lehmann,D. Leanne Jones,Marc Tatar +8 more
TL;DR: It is reported that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling, suggesting that signals from the gonad regulate lifespan andmodulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved.
Journal ArticleDOI
Towards synthetic biological approaches to resource utilization on space missions
TL;DR: The results provide a glimpse of the intriguing potential of ‘space synthetic biology’, and help focus related efforts for immediate, near-term impact.
Journal ArticleDOI
Analysis of DNA Repair and Protection in the Tardigrade Ramazzottius varieornatus and Hypsibius dujardini after Exposure to UVC Radiation
Daiki D. Horikawa,John Cumbers,John Cumbers,Iori Sakakibara,Iori Sakakibara,Iori Sakakibara,Dana Rogoff,Stefan Leuko,Raechel Harnoto,Kazuharu Arakawa,Toshiaki Katayama,Takekazu Kunieda,Atsushi Toyoda,Asao Fujiyama,Lynn J. Rothschild,Lynn J. Rothschild,Lynn J. Rothschild +16 more
TL;DR: It is proposed that UV radiation tolerance in tardigrades is due to the both high capacities of DNA damage repair and DNA protection, a two-pronged survival strategy.