T
Thomas H. Hutchinson
Researcher at University of Plymouth
Publications - 182
Citations - 12608
Thomas H. Hutchinson is an academic researcher from University of Plymouth. The author has contributed to research in topics: Population & Vitellogenin. The author has an hindex of 62, co-authored 176 publications receiving 11537 citations. Previous affiliations of Thomas H. Hutchinson include University of Liverpool & Mississippi State University.
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Journal ArticleDOI
Effects of the synthetic estrogen 17α‐ethinylestradiol on the life‐cycle of the fathead minnow (Pimephales promelas)
Reinhard Länge,Thomas H. Hutchinson,Charlotte P. Croudace,Fred Siegmund,Hermann Schweinfurth,Peter Hampe,Grace H. Panter,John P. Sumpter +7 more
TL;DR: A fish full life‐cycle (FFLC) study was conducted for 17α‐ethinylestradiol (EE2) using the fathead minnow, Pimephales promelas, and found male fish exposed to this level of EE2 failed to develop normal secondary sexual characteristics and a lack of sexual differentiation occurred in males at concentrations ≥4.0 ng/L.
Journal ArticleDOI
Relative potencies and combination effects of steroidal estrogens in fish.
Karen L. Thorpe,Rob I. Cummings,Thomas H. Hutchinson,Martin Scholze,Geoff Brighty,John P. Sumpter,Charles R. Tyler +6 more
TL;DR: The ability of each individual steroid to contribute to the overall effect of a mixture, even at individual no-effect concentrations, combined with the high estrogenic potency of the steroids, particularly the synthetic steroid EE2, emphasizes the need to consider the total estrogenic load of these chemicals in the authors' waterways.
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Adverse Outcome Pathway (AOP) Development I: Strategies and Principles
Daniel L. Villeneuve,Daniel L. Villeneuve,Doug Crump,Doug Crump,Natàlia Garcia-Reyero,Natàlia Garcia-Reyero,Markus Hecker,Markus Hecker,Thomas H. Hutchinson,Thomas H. Hutchinson,Carlie A. LaLone,Carlie A. LaLone,Brigitte Landesmann,Brigitte Landesmann,Teresa Lettieri,Teresa Lettieri,Sharon Munn,Sharon Munn,Malgorzata Nepelska,Malgorzata Nepelska,Mary Ann Ottinger,Mary Ann Ottinger,Lucia Vergauwen,Lucia Vergauwen,Maurice Whelan,Maurice Whelan +25 more
TL;DR: Consideration of these principles addresses many of the current uncertainties regarding the AOP framework and its application and is intended to foster greater consistency in AOP development.
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Sources, impacts and trends of pharmaceuticals in the marine and coastal environment
TL;DR: The sources, impacts and concentrations of pharmaceuticals in marine and coastal environments are reviewed to identify knowledge gaps and focused case studies are suggested as a priority for future research.
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Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology.
TL;DR: The term 'ecotoxicogenomics' is proposed to describe the integration of genomics (transcriptomics, proteomics and metabolomics) into ecotoxicology, which may provide a better mechanistic understanding of aquatic ecot toxicology.