Thomas Hawighorst

TL;DR: The occurrence and biological significance of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice are established and VEGF-C is identified as a molecular link between tumor lymphang iogenesis and metastasis.

TL;DR: The presence of intratumoral lymphatics and enlargement of lymphatic vessels at the tumor periphery in vascular endothelial growth factor (VEGF)-C-overexpressing human melanomas transplanted onto nude mice is demonstrated and VEGF-C is identified as multifunctional factor involved in regulating tumor lymphangiogenesis, angiogenic, and immune response.

TL;DR: TSP-2 is established as a potent endogenous inhibitor of tumor growth and angiogenesis and combined overexpression of TSP-1 and T SP-2 completely prevented tumor formation.

TL;DR: It is demonstrated that TSP‐1 preferentially interfered with wound healing‐associated angiogenesis, rather than with theAngiogenesis associated with normal development and skin homeostasis, and suggested that therapeutic application of angiogenic inhibitors might potentially be associated with impaired wound vascularization and tissue repair.

TL;DR: An inhibitory role of Ang1/Tie2 receptor-mediated vessel maturation in SCC growth is identified and up-regulation of its antagonist, Ang2, during early-stage epithelial tumorigenesis contributes to the angiogenic switch by counteracting specific vessel-stabilizing effects of Ang 1.