Thomas J. Downey

TL;DR: Correlations in gene expression levels and comparisons for significant gene expression changes in this subset were calculated, and showed considerable divergence across the different platforms, suggesting the need for establishing industrial manufacturing standards, and further independent and thorough validation of the technology.

TL;DR: In Down syndrome, there is a primary transcriptional effect of disruption of chromosome 21 gene expression, without a pervasive secondary effect on the remaining transcriptome, which suggests molecular changes that may underlie the Down syndrome phenotypes.

TL;DR: This combined method allowed us to distinguish related individuals from those having atypical heterozygosity rates and determine which individuals were outliers with respect to their designated population, and further identified distant relatedness between individuals within populations.

TL;DR: Artificial neural networks are introduced, flexible nonlinear modeling techniques that test a model's generality by applying its estimates against "future" data and have potential for overcoming some shortcomings of linear models.

TL;DR: Test the hypothesis that microarray expression profiles can be used to diagnose sepsis, distinguishing in vivo between sterile and infectious causes of systemic inflammation, and identified nine mouse common inflammatory response genes, six of which were mapped into a single pathway using contemporary pathway analysis tools.