T
Thomas J. Freeman
Researcher at Cardiff University
Publications - 3
Citations - 17
Thomas J. Freeman is an academic researcher from Cardiff University. The author has contributed to research in topics: Ex vivo & Retina. The author has an hindex of 1, co-authored 3 publications receiving 10 citations.
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Journal ArticleDOI
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Charles E. Evans,Rhian S. Thomas,Thomas J. Freeman,Martha Hvoslef-Eide,Mark Andrew Good,Emma Jane Kidd +5 more
TL;DR: An antibody, 2B3, is used that binds to APP at the BACE cleavage site, inhibiting Aβ production and improves memory for object-in-place associations and working memory in a foraging task in PDAPP mice and WT mice.
Journal ArticleDOI
Red Light Irradiation In Vivo Upregulates DJ-1 in the Retinal Ganglion Cell Layer and Protects against Axotomy-Related Dendritic Pruning.
Kathy Beirne,Thomas J. Freeman,Malgorzata Barbara Rozanowska,Marcela Votruba,Marcela Votruba +4 more
TL;DR: In this article, photobiomodulation with red light provided neuroprotection to retinal ganglion cells (RGCs) when administered ex vivo to wild-type retinal explants.
Journal ArticleDOI
New avenues for therapy in mitochondrial optic neuropathies
Wing Sum Vincent Ng,Matthieu Trigano,Thomas J. Freeman,Carmine Varrichio,Dinesh Kumar Kandaswamy,Ben Newland,Andrea Brancale,Malgorzata Barbara Rozanowska,Marcela Votruba +8 more
TL;DR: The genetic and clinical features of ADOA and LHON are summarized and what new avenues there may be for therapeutic intervention are examined, to explore how present and possible future treatments might provide hope for those suffering from these conditions.