T
Thomas J. Louie
Researcher at University of Calgary
Publications - 109
Citations - 10488
Thomas J. Louie is an academic researcher from University of Calgary. The author has contributed to research in topics: Clostridium difficile & Medicine. The author has an hindex of 41, co-authored 89 publications receiving 9263 citations. Previous affiliations of Thomas J. Louie include Alberta Health Services & Calgary General Hospital.
Papers
More filters
Journal ArticleDOI
Fidaxomicin versus Vancomycin for Clostridium difficile Infection
Thomas J. Louie,Mark A. Miller,Kathleen M. Mullane,Karl Weiss,Arnold Lentnek,Yoav Golan,Sherwood L. Gorbach,Pamela Sears,Youe-Kong Shue +8 more
TL;DR: Fidaxomicin was associated with a significantly lower rate of recurrence of C. difficile infection associated with non–North American Pulsed Field type 1 strains and the adverse-event profile was similar for the two therapies.
Journal ArticleDOI
Novel Multiplex PCR Assay for Characterization and Concomitant Subtyping of Staphylococcal Cassette Chromosome mec Types I to V in Methicillin-Resistant Staphylococcus aureus
TL;DR: A novel multiplex PCR assay allowing for concomitant detection of the methicillin resistance (mecA gene) to facilitate detection and classification of all currently described SCCmec types and subtypes I, II, III, IVa, b, c, d, and V is demonstrated.
Journal ArticleDOI
Treating Clostridium difficile Infection With Fecal Microbiota Transplantation
Johan S. Bakken,Thomas J. Borody,Lawrence J. Brandt,Joel V. Brill,Daniel C. DeMarco,Marc Alaric Franzos,Colleen R. Kelly,Alexander Khoruts,Thomas J. Louie,Lawrence P. Martinelli,Thomas A. Moore,George Russell,Christina M. Surawicz +12 more
TL;DR: Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured.
Journal ArticleDOI
Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results From Two Multinational, Randomized, Controlled Trials
Stuart Johnson,Thomas J. Louie,Dale N. Gerding,Oliver A. Cornely,Scott Chasan-Taber,David Fitts,Steven P Gelone,Colin Broom,David M. Davidson +8 more
TL;DR: Tolevamer was inferior to antibiotic treatment of CDI, and metronidazole was superior to vancomycin, and the primary endpoint was clinical success, defined as resolution of diarrhea and absence of severe abdominal discomfort for more than 2 consecutive days.
Journal ArticleDOI
Effect of Oral Capsule- vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.
Dina Kao,Brandi Roach,Marisela Silva,Paul L. Beck,Kevin Rioux,Gilaad G. Kaplan,Hsiu-Ju Chang,Stephanie Coward,Karen J. Goodman,Huiping Xu,Karen L. Madsen,Andrew Mason,Gane Ka-Shu Wong,Juan Jovel,Jordan Patterson,Thomas J. Louie +15 more
TL;DR: Among adults with RCDI, FMT via oral capsules was not inferior to delivery by colonoscopy for preventing recurrent infection over 12 weeks and treatment with oral capsules may be an effective approach to treating RCDi.