Treating Clostridium difficile Infection With Fecal Microbiota Transplantation
Johan S. Bakken,Thomas J. Borody,Lawrence J. Brandt,Joel V. Brill,Daniel C. DeMarco,Marc Alaric Franzos,Colleen R. Kelly,Alexander Khoruts,Thomas J. Louie,Lawrence P. Martinelli,Thomas A. Moore,George Russell,Christina M. Surawicz +12 more
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TLDR
Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2011-12-01 and is currently open access. It has received 904 citations till now. The article focuses on the topics: Transplantation & Clostridium difficile.read more
Citations
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura,Jeremiah J. Faith,Federico E. Rey,Jiye Cheng,Alexis E. Duncan,Andrew L. Kau,Nicholas W. Griffin,Vincent Lombard,Bernard Henrissat,Bernard Henrissat,James R. Bain,Michael J. Muehlbauer,Olga Ilkayeva,Clay F. Semenkovich,Katsuhiko Funai,David K. Hayashi,Barbara J. Lyle,Margaret C. Martini,Luke K. Ursell,Jose C. Clemente,Will Van Treuren,William A. Walters,Rob Knight,Rob Knight,Christopher B. Newgard,Andrew C. Heath,Jeffrey I. Gordon +26 more
TL;DR: The results reveal that transmissible and modifiable interactions between diet and microbiota influence host biology and that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids.
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Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
L. Clifford McDonald,Dale N. Gerding,Stuart Johnson,Stuart Johnson,Johan S. Bakken,Karen C. Carroll,Susan E. Coffin,Erik R. Dubberke,Kevin W. Garey,Carolyn V. Gould,Ciaran P. Kelly,Vivian G. Loo,Julia S. Sammons,Thomas J. Sandora,Mark H. Wilcox +14 more
TL;DR: This guideline updates recommendations regarding epidemiology, diagnosis, treatment, infection prevention, and environmental management on Clostridium difficile infection in adults and includes recommendations for children.
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Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections
Christina M. Surawicz,Lawrence J. Brandt,David G. Binion,Ashwin N. Ananthakrishnan,Scott R. Curry,Peter H. Gilligan,Lynne V. McFarland,Mark Mellow,Brian S. Zuckerbraun +8 more
TL;DR: Treatment of patients with CDI should be stratified depending on whether they have mild-to-moderate, severe, or complicated disease, and a classification of disease severity is proposed to guide therapy that is useful for clinicians.
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Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial
Paul Moayyedi,Michael G. Surette,Peter T. Kim,Peter T. Kim,Josie Libertucci,Melanie Wolfe,Catherine Onischi,David Armstrong,John Marshall,Zain Kassam,Walter Reinisch,Christine H. Lee +11 more
TL;DR: Fecal microbiota transplantation induces remission in a significantly greater percentage of patients with active UC than placebo, with no difference in adverse events.
Journal ArticleDOI
Microbiota-mediated colonization resistance against intestinal pathogens.
Charlie G. Buffie,Eric G. Pamer +1 more
TL;DR: How immune- mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota is discussed and recent advances characterizing the ability of different Commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts are reviewed.
References
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Host-Bacterial Mutualism in the Human Intestine
TL;DR: New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements the authors' biology in ways that are mutually beneficial.
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Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
Stuart H. Cohen,Dale N. Gerding,Stuart Johnson,Ciaran P. Kelly,Vivian G. Loo,L. Clifford McDonald,Jacques Pépin,Mark H. Wilcox +7 more
TL;DR: This guideline updates recommendations regarding epidemiology, diagnosis, treatment, and infection control and environmental management of Clostridium difficile.
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Clostridium difficile infection: new developments in epidemiology and pathogenesis
TL;DR: Since 2001, the prevalence and severity of C. difficile infection has increased significantly, which has led to increased research interest and the discovery of new virulence factors, and has expanded and focused the development of new treatment and prevention regimens.
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Clostridium difficile — More Difficult Than Ever
Ciaran P. Kelly,J. Thomas Lamont +1 more
TL;DR: Recent changes in the epidemiology of C. difficile have become both more prevalent and more virulent and the use of new antibiotics, probiotics, immunotherapy, and even bacteriotherapy is discussed.
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A Comparison of Vancomycin and Metronidazole for the Treatment of Clostridium difficile–Associated Diarrhea, Stratified by Disease Severity
TL;DR: The findings suggest that metronidazole and vancomycin are equally effective for the treatment of mild CDAD, but vancomYcin is superior for treating patients with severe CDAD.