Thomas M. O’Connell

TL;DR: It is demonstrated that microbiota have a strong effect on energy homeostasis in the colon compared to other tissues and this tissue specificity is due to colonocytes utilizing bacterially produced butyrate as their primary energy source.

TL;DR: The tricarboxylic acid cycle is identified as a pathway commonly regulated by acylation and validated malate dehydrogenase as a key target and data uncover a fundamental relationship between reactive acyl-CoA species and proteins and define a new regulatory paradigm in metabolism.

TL;DR: It is demonstrated that the pattern of endogenous metabolites in urine could predict susceptibility to acetaminophen‐induced liver injury in rats, and this “early‐intervention pharmaco‐metabonomics” approach should now be tested in clinical trials of other potentially hepatotoxic drugs.

TL;DR: A comprehensive and systems level metabolomics approach is applied to characterize the metabolic perturbations in murine models of cancer‐induced and chemotherapy‐induced cachexia.

TL;DR: Compared to a traditional HFD model, the CAF diet provides a robust model for diet-induced human obesity, which models Metabolic Syndrome-related mitochondrial dysfunction in serum, muscle, and adipose, along with pro-inflammatory metabolite alterations, and suggest that modifying the availability or metabolism of saturated fatty acids may limit the inflammation associated with obesity leading to Metabolic syndrome.