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Grant A. Mitchell
Researcher at Université de Montréal
Publications - 222
Citations - 14812
Grant A. Mitchell is an academic researcher from Université de Montréal. The author has contributed to research in topics: Lipolysis & Gene. The author has an hindex of 59, co-authored 214 publications receiving 13256 citations. Previous affiliations of Grant A. Mitchell include Canadian Institutes of Health Research & French Institute of Health and Medical Research.
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Journal ArticleDOI
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Saverio Cinti,Grant A. Mitchell,Giorgio Barbatelli,Incoronata Murano,Enzo Ceresi,Emanuela Faloia,Shupei Wang,Mélanie Fortier,Andrew S. Greenberg,Martin S. Obin +9 more
TL;DR: It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation.
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A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).
Carol J. Gallione,Gabriela M. Repetto,Eric Legius,Anil K. Rustgi,Susan Schelley,Sabine Tejpar,Grant A. Mitchell,Éric Drouin,Cornelius J.J. Westermann,Douglas A. Marchuk +9 more
TL;DR: Patients with juvenile polyposis who have an MADH4 mutation should be screened for the vascular lesions associated with hereditary haemorrhagic telangiectasia, especially occult arteriovenous malformations in visceral organs that may otherwise present suddenly with serious medical consequences.
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Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
Vamsi K. Mootha,Pierre Lepage,Kathleen Miller,Jakob Bunkenborg,Michael R. Reich,Majbrit Hjerrild,Terrye Delmonte,Amelie Villeneuve,Robert Sladek,Fenghao Xu,Grant A. Mitchell,Charles Morin,Matthias Mann,Thomas J. Hudson,Brian D. Robinson,John D. Rioux,Eric S. Lander +16 more
TL;DR: Data sets of RNA and protein expression are used to identify the gene causing Leigh syndrome, French-Canadian type (LSFC), a human cytochrome c oxidase deficiency that maps to chromosome 2p16-21, providing definitive genetic proof that LRPPRC indeed causes LSFC.
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The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Przemyslaw Sapieha,Mirna Sirinyan,Mirna Sirinyan,David Hamel,Karine Zaniolo,Jean-Sébastien Joyal,Jean-Sébastien Joyal,Jang Hyeon Cho,Jean Claude Honoré,Elsa Kermorvant-Duchemin,Daya R. Varma,Sophie Tremblay,Martin Leduc,Lenka Rihakova,Pierre Hardy,William Klein,Xiuqian Mu,Orval A. Mamer,Pierre Lachapelle,Adriana Di Polo,Christian Beauséjour,Gregor Andelfinger,Grant A. Mitchell,Florian Sennlaub,Florian Sennlaub,Florian Sennlaub,Sylvain Chemtob +26 more
TL;DR: It is shown that succinate accumulates in the hypoxic retina of rodents and, via its cognate receptor G protein–coupled receptor-91 (GPR91), is a potent mediator of vessel growth in the settings of both normal retinal development and proliferative ischemic retinopathy.
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Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.
TL;DR: Consideration of ketone body metabolism reveals the mechanisms underlying the extreme fragility of dietary ketosis to carbohydrate intake and highlights areas for further study.