Thomas M. Schiele

TL;DR: It is strongly suggested that collagen activation induces NAD(P)H oxidase-dependent O release in platelets, which in turn enhances availability of released ADP, resulting in increased platelet recruitment.

TL;DR: This study compared CMRI with CA plus a standard invasive functional assessment (FFR) and demonstrated that CMRI is able to distinguish haemodynamically relevant from non-relevant coronary lesions with a high sensitivity and specificity and may contribute to clinical decision-making.

TL;DR: This study suggests a dose-response relationship on hyperemia for intracoronary adenosine doses >60 microg and should be the preferred mode of application for the assessment of FFR.

TL;DR: Optical coherence tomography is superior to intravascular ultrasound for the detection and characterization of coronary atherosclerotic plaque composition, specifically for the differentiation of noncalcified, lipid-rich, or fibrous plaque.

TL;DR: The rationale for the development of selective COX-2 inhibitors and the pathophysiological consequences of selective inhibition of COx-2 with special regard to vasoactive prostaglandins are outlined and the consequences that should be drawn are critically discussed.