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Thomas Martin

Researcher at University of California, San Francisco

Publications -  311
Citations -  17918

Thomas Martin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Exocytosis. The author has an hindex of 73, co-authored 242 publications receiving 15771 citations. Previous affiliations of Thomas Martin include Institut national de la recherche agronomique & University of Western Australia.

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A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.

TL;DR: The results indicate that PKC is neither necessary nor sufficient for Ca( 2+)-activated secretion, whereas other cytosolic proteins are required; and the stimulation of Ca(2+)- activated secretion by PKC may be largely mediated through the phosphorylation of p145, a recently characterized 145-kDa brain protein.
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Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells.

TL;DR: It is found that full downregulation of synaptotagmin I and IX, which co-reside on vesicles in PC12 cells, completely abolished Ca2+-dependent vesicle exocytosis, which indicated a redundancy in function for these isoforms.
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Novel Interactions of CAPS (Ca2+-dependent Activator Protein for Secretion) with the Three Neuronal SNARE Proteins Required for Vesicle Fusion

TL;DR: The results suggest that SNARE complex formation promoted by CAPS may be mediated by direct interactions of CAPS with each of the three SNARE proteins required for vesicle exocytosis.
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3D conformal HDR brachytherapy and external beam irradiation combined with temporary androgen deprivation in the treatment of localized prostate cancer.

TL;DR: 3D conformal HDR brachytherapy and EBRT combined with temporary androgen deprivation is an effective treatment modality for prostate cancer with minimal associated toxicity and encouraging biochemical control rates after a median follow-up of 2.6 years.