T
Thomas Martin
Researcher at University of California, San Francisco
Publications - 311
Citations - 17918
Thomas Martin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Exocytosis. The author has an hindex of 73, co-authored 242 publications receiving 15771 citations. Previous affiliations of Thomas Martin include Institut national de la recherche agronomique & University of Western Australia.
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Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells
TL;DR: Recombinant C2 domains derived from the cytoplasmic domains of syts I–XI are used to interfere with endogenous syt–effector interactions during Ca2+-triggered exocytosis from cracked PC12 cells, suggesting that syts trigger fusion via their Ca2-regulated interactions with t-SNAREs and PIP2, target molecules known to play critical roles in exocyTosis.
Journal ArticleDOI
Multiple Myeloma, version 3.2018: Featured updates to the NCCN guidelines
Shaji Kumar,Natalie S. Callander,Melissa Alsina,Djordje Atanackovic,J. Sybil Biermann,Jorge J. Castillo,Jason C. Chandler,Caitlin Costello,Matthew Faiman,Henry C. Fung,Kelly N. Godby,Craig C. Hofmeister,Leona Holmberg,Sarah A. Holstein,Carol Ann Huff,Yubin Kang,Adetola A. Kassim,Michaela Liedtke,Ehsan Malek,Thomas Martin,Vishala Neppalli,James L. Omel,Noopur Raje,Seema Singhal,George Somlo,Keith Stockerl-Goldstein,Donna M. Weber,Joachim Yahalom,Rashmi Kumar,Dorothy A. Shead +29 more
TL;DR: The important updates/changes specific to the myeloma therapy options in the 2018 version of the NCCN Guidelines for Multiple Myeloma are highlighted.
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Phosphoinositides as spatial regulators of membrane traffic
TL;DR: The roles played by phosphoinositides in aspects of secretory granule formation, fusion and endocytosis indicate the importance of phosphorylated lipids for neurotransmitter release.
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Thyrotropin-releasing hormone (TRH) selectively and rapidly stimulates phosphatidylinositol turnover in GH pituitary cells: a possible second step of TRH action.
Claudia A. Sutton,Thomas Martin +1 more
TL;DR: The rapid onset of the response reported here suggests that this event may play a role in mediating the PRL-releasing effects of TRH and bombesin in GH cells.
Journal ArticleDOI
Synaptotagmin IX Regulates Ca2+-dependent Secretion in PC12 Cells *
TL;DR: The results support the idea that Syt family proteins that co-reside on secretory vesicles may function cooperatively and redundantly as potential Ca2+ sensors for exocytosis.