T
Thomas Martin
Researcher at University of California, San Francisco
Publications - 311
Citations - 17918
Thomas Martin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Exocytosis. The author has an hindex of 73, co-authored 242 publications receiving 15771 citations. Previous affiliations of Thomas Martin include Institut national de la recherche agronomique & University of Western Australia.
Papers
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letters-and-commentsDOI
Teclistamab in Relapsed or Refractory Multiple Myeloma.
Philippe Moreau,Alfred L. Garfall,N. W. C. J. van de Donk,Hareth Nahi,Jesús F. San Miguel,Albert Oriol,Ajay K. Nooka,Thomas Martin,Laura Rosiñol,Ajai Chari,Lionel Karlin,Lotfi Benboubker,Maria-Victoria Mateos,Nizar J. Bahlis,Rakesh Popat,Britta Besemer,Joaquin Martinez-Lopez,Surbhi Sidana,Michel Delforge,Lixia Pei,D. Trancucci,Raluca I. Verona,Suzette Girgis,Shun Xin Wang Lin,Yunsi Olyslager,M. Jaffe,Clarissa M. Uhlar,Tara Stephenson,Rian Van Rampelbergh,Arnob Banerjee,Jenna D. Goldberg,Rachel Kobos,Amrita Krishnan,Saad Z. Usmani +33 more
TL;DR: Teclistamab resulted in a high rate of deep and durable response in patients with triple-class-exposed relapsed or refractory multiple myeloma, and was found to have no minimal residual disease.
Journal ArticleDOI
Docking and fusion in neurosecretion
L. J. Robinson,Thomas Martin +1 more
TL;DR: Current evidence suggests that NSF functions during an ATP-dependent step after docking but before fusion, and may function to liberate SNARE proteins from complexes so that the proteins on apposed membranes align in a parallel fashion to bring SVs into close contact with the plasma membrane for fusion.
Journal ArticleDOI
Membrane Association Domains in Ca2+-dependent Activator Protein for Secretion Mediate Plasma Membrane and Dense-core Vesicle Binding Required for Ca2+-dependent Exocytosis
Ruslan N. Grishanin,Vadim A. Klenchin,Kelly M. Loyet,Judith A. Kowalchyk,Kyoungsook Ann,Thomas Martin +5 more
TL;DR: The presence of two membrane association domains with distinct binding specificities may enable CAPS to bind both target membranes to facilitate DCV-plasma membrane fusion.
Book ChapterDOI
PC12 Cells as a Model for Studies of Regulated Secretion in Neuronal and Endocrine Cells
TL;DR: This chapter reviews a number of methods that are useful for studies of the regulated dense core vesicle secretory pathway, including protocols for maintaining cells and preserving their phenotype.
Journal ArticleDOI
Rapid regulated dense-core vesicle exocytosis requires the CAPS protein
Marjan Slak Rupnik,Mateja Erdani Kreft,Sujit Kumar Sikdar,Sonja Grilc,Rok Romih,Gregor Zupančič,Thomas Martin,Robert Zorec +7 more
TL;DR: The results indicate that dense-core vesicle exocytosis in melanotrophs occurs by two parallel pathways, the faster pathway exhibits high sensitivity to Ca(2+) and requires the presence of CAPS, which appears to act at a late stage in the secretory pathway.