T
Thomas Martin
Researcher at University of California, San Francisco
Publications - 311
Citations - 17918
Thomas Martin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Exocytosis. The author has an hindex of 73, co-authored 242 publications receiving 15771 citations. Previous affiliations of Thomas Martin include Institut national de la recherche agronomique & University of Western Australia.
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Interim results from PX-171-006, a phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM).
Maria Wang,William I. Bensinger,Thomas Martin,M. Alsina,David S. Siegel,Nashat Y. Gabrail,Parameswaran Hari,Seema Singhal,Robert Vescio,S. E. Assouline,Lori Kunkel,M. Vallone,Alvin Wong,Ruben Niesvizky +13 more
TL;DR: CRd is well-tolerated in pts previously treated with BTZ, LEN, and/or THAL, and the maximum protocol dose (MPD) was reached and no dose-limiting toxicities were reported.
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Detection of Multiple Myeloma Cells in Peripheral Blood Using High-Throughput Sequencing Assay
Amitabha Mazumder,Malek Faham,Mark A. Fiala,Mark Klinger,Thomas Martin,Jeesun Park,Ravi Vij,Jeffrey L. Wolf +7 more
TL;DR: A cohort of MM patients was assessed using a sequencing based platform, LymphoSIGHT, and the myeloma minimal residual disease could be detected in peripheral blood (PB), with a sensitivity of 1 cancer cell per million leukocytes.
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Extended RNA synthesis in isolated nuclei from rat pituitary tumor cells.
TL;DR: Qualitative differences in the nuclear and supernatant RNAs, the kinetics of appearance of the latter, and the differential effect of 3'-dATP on the extranuclear appearance of supernatante RNAs suggest that a process resembling nuclear-cytoplasmic RNA transport occurred in this cell-free nuclear system.
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Reconstitution of a solubilized membrane but not cytosolic phospholipase C with membrane-associated Gp from GH3 cells.
TL;DR: Results indicate that the Gp-regulated PL C in GH3 cell membranes is an extrinsic membrane protein that can be extracted reversibly at high ionic strength and can be distinguished from cytosolic PL C isoenzymes.
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Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results
Matthew J. Wieduwilt,Nela Pawlowska,Scott Thomas,Rebecca L. Olin,Aaron C Logan,Lloyd E. Damon,Thomas Martin,McNancy Kang,Peter H. Sayre,Wanda Boyer,Karin M.L. Gaensler,Kirsten Anderson,Pamela N. Munster,Charalambos Andreadis +13 more
TL;DR: Panobinostat with “7+3” for older patients with AML was well tolerated and increased histone acetylation 4 and 24 hours after panobinostats was significantly associated with CR/CRi.