T
Thomas Münch
Researcher at University of Tübingen
Publications - 41
Citations - 2118
Thomas Münch is an academic researcher from University of Tübingen. The author has contributed to research in topics: Retina & Retinal ganglion. The author has an hindex of 15, co-authored 38 publications receiving 1824 citations. Previous affiliations of Thomas Münch include Friedrich Miescher Institute for Biomedical Research & Helen Wills Neuroscience Institute.
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Journal ArticleDOI
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.
Pamela Lagali,D. Balya,Gautam B. Awatramani,Gautam B. Awatramani,Thomas Münch,Douglas S. Kim,Volker Busskamp,Constance L. Cepko,Botond Roska +8 more
TL;DR: To restore photosensitivity, a light-activated cation channel is genetically targeted to second-order neurons of degenerated retinas in vivo in the Pde6brd1 mouse model, and ON bipolar cells that were engineered to be photosensitive induced light-evoked spiking activity in ganglion cells.
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Mechanisms and circuitry underlying directional selectivity in the retina
TL;DR: This work shows that a presynaptic interneuron, the starburst amacrine cell, delivers direct inhibition to directionally selective cells, thereby ensuring robust directional selectivity in the retina.
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Approach sensitivity in the retina processed by a multifunctional neural circuit.
Thomas Münch,Thomas Münch,Rava Azeredo da Silveira,Sandra Siegert,Tim J. Viney,Gautam B. Awatramani,Gautam B. Awatramani,Botond Roska +7 more
TL;DR: An approach-sensitive ganglion cell type in the mouse retina is identified, elements of its afferent neural circuit are resolved, and how these confer approach sensitivity on the ganglions are described.
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Retinal output changes qualitatively with every change in ambient illuminance.
Alexandra Tikidji-Hamburyan,Katja Reinhard,Hartwig Seitter,Anahit Hovhannisyan,Christopher A. Procyk,Annette E. Allen,Martin Schenk,Robert J. Lucas,Thomas Münch +8 more
TL;DR: The results suggest that the retinal code is not fixed but varies with every change of ambient luminance, which raises questions about signal processing within the retina and has implications for visual processing in higher brain areas.
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Neuropeptides regulate swimming depth of Platynereis larvae
Markus Conzelmann,Sarah-Lena Offenburger,Albina Asadulina,Timea Keller,Thomas Münch,Gáspár Jékely +5 more
TL;DR: The findings indicate that Platynereis larvae have depth-regulating peptidergic neurons that directly translate sensory inputs into locomotor output on effector cilia, and propose that the simple circuitry found in these ciliated larvae represents an ancestral state in nervous system evolution.