Thomas O. Helmbrecht

TL;DR: A flexible method for high-resolution interrogation of circuit function is introduced, which combines simultaneous 3D two-photon stimulation of multiple targeted neurons, volumetric functional imaging, and quantitative behavioral tracking, which enables linking behavior to circuit activity with unprecedented resolution.

TL;DR: It is concluded that specific labeled lines guide object-directed behavior in the larval zebrafish brain through a tectum-generated space code sufficient to steer orienting movements.

TL;DR: This study reports the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology and shows that a combination of Gal4 and Cre transgenes allows intersectional expression of a fluorescent reporter in regions where the expression of the two drivers overlaps.

TL;DR: It is concluded that local cell-type composition and connectivity across the tectum are adapted to the processing of location-dependent, behaviorally relevant object features.

TL;DR: In this paper, the authors used single-cell transcriptomics to identify marker genes for >30 mature RGCs and several developmental intermediates and used this dataset to engineer transgenic driver lines, enabling specific experimental access to a subset of RGC types.