T
Thomas S. Deisboeck
Researcher at Harvard University
Publications - 118
Citations - 6485
Thomas S. Deisboeck is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Tumor progression. The author has an hindex of 41, co-authored 117 publications receiving 6011 citations. Previous affiliations of Thomas S. Deisboeck include Wellesley College & Massachusetts Institute of Technology.
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Simulated brain tumor growth dynamics using a three-dimensional cellular automaton.
TL;DR: A novel and versatile three-dimensional cellular automaton model of brain tumor growth that shows that macroscopic tumor behavior can be realistically modeled using microscopic parameters and demonstrates the flexibility of the model by showing the emergence, and eventual dominance, of a second tumor clone with a different genotype.
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Multiscale Cancer Modeling
TL;DR: In this review, the most recent and important multiscale cancer modeling works that have successfully established a mechanistic link between different biological scales are introduced and biophysical, biochemical, and biomechanical factors are considered in these models.
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Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses
Keiro Ikeda,Tomotsugu Ichikawa,Hiroaki Wakimoto,Jonathan S. Silver,Thomas S. Deisboeck,Dianne M. Finkelstein,Griffith R. Harsh,David N. Louis,Raymond T. Bartus,Fred H. Hochberg,E. Antonio Chiocca +10 more
TL;DR: Cyclophosphamide treatment of rats with large single or multiple intracerebral tumors substantially increased viral survival and propagation, leading to neoplastic regression.
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Glioma Expansion in Collagen I Matrices: Analyzing Collagen Concentration-Dependent Growth and Motility Patterns
Laura J. Kaufman,Clifford P. Brangwynne,Karen E. Kasza,Emmanouela Filippidi,Vernita Gordon,Thomas S. Deisboeck,David A. Weitz +6 more
TL;DR: Studying invasion on the length scale of individual invading cells with a combination of confocal and coherent anti-Stokes Raman scattering microscopy reveals that the invasive GBM cells rely heavily on cell-matrix interactions during invasion and remodeling.
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Does tumor growth follow a "universal law"?
Caterina Guiot,Piero Giorgio Degiorgis,Pier Paolo Delsanto,Pier Paolo Delsanto,Pietro Gabriele,Thomas S. Deisboeck,Thomas S. Deisboeck +6 more
TL;DR: In this paper, a general model for the ontogenetic growth of living organisms has been recently proposed and the extension of this model to the growth of solid malignant tumors is investigated.