T
Thomas Schmidt
Researcher at Swiss Institute of Bioinformatics
Publications - 52
Citations - 3487
Thomas Schmidt is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Gene & Thermal energy storage. The author has an hindex of 23, co-authored 50 publications receiving 2373 citations. Previous affiliations of Thomas Schmidt include Lüneburg University & University of Zurich.
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Journal ArticleDOI
Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data
Luca Gerosa,Bart R. B. Haverkorn van Rijsewijk,Dimitris Christodoulou,Karl Kochanowski,Thomas Schmidt,Elad Noor,Uwe Sauer +6 more
TL;DR: P pseudo-transition analysis is introduced, an approach that uses multiple steady-state observations of (13)C-resolved fluxes, metabolites, and transcripts to infer which regulatory events drive metabolic adaptations following environmental transitions, and shows that some dynamic transitions can be approximated as monotonic shifts between steady- state extremes.
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Disentangling the mechanisms shaping the surface ocean microbiota
Ramiro Logares,Ramiro Logares,Ina M. Deutschmann,Pedro C. Junger,Caterina R. Giner,Caterina R. Giner,Anders K. Krabberød,Thomas Schmidt,Laura Rubinat-Ripoll,Mireia Mestre,Mireia Mestre,Mireia Mestre,Guillem Salazar,Guillem Salazar,Clara Ruiz-González,Marta Sebastián,Marta Sebastián,Colomban de Vargas,Silvia G. Acinas,Carlos M. Duarte,Josep M. Gasol,Josep M. Gasol,Ramon Massana +22 more
TL;DR: The differential action of ecological mechanisms seems to cause contrasting biogeography, in the tropical and subtropical ocean, among the smallest surface plankton, prokaryotes and picoeukaryotes, suggesting that the idiosyncrasy of the main constituents of the ocean microbiota should be considered in order to understand its current and future configuration.
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Microbiota-Derived Hydrogen Fuels Salmonella Typhimurium Invasion of the Gut Ecosystem
Lisa A. Maier,Rounak Vyas,Carmen Dolores Cordova,Helen Lindsay,Thomas Schmidt,Sandrine Brugiroux,Balamurugan Periaswamy,Rebekka Bauer,Alexander Sturm,Frank Schreiber,Christian von Mering,Mark D. Robinson,Bärbel Stecher,Wolf-Dietrich Hardt +13 more
TL;DR: It is discovered that initial growth of Salmonella Typhimurium in the unperturbed gut is powered by S. Tm hyb hydrogenase, which facilitates consumption of hydrogen, a central intermediate of microbiota metabolism that can be subverted by pathogens and might offer opportunities to prevent infection.
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A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells.
TL;DR: Evidence is presented that the p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding‐protein‐dependent transport systems of Gram‐negative bacteria, and it is suggested that p37 is part a homologous, high‐affinity transport system in M. hyorhinis, a Gram‐positive bacterium.
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The Drosophila melanogaster sex-peptide: A molecular analysis of structure-function relationships
TL;DR: The N-terminal 7 amino acids are not needed for sex-peptide function, whereas the disulfide bridge appears essential, and all results are consistent with the assumption of only one target molecule for both reactions which is accessible via hemolymph.