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Thomas Schmidt

Researcher at Swiss Institute of Bioinformatics

Publications -  52
Citations -  3487

Thomas Schmidt is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Gene & Thermal energy storage. The author has an hindex of 23, co-authored 50 publications receiving 2373 citations. Previous affiliations of Thomas Schmidt include Lüneburg University & University of Zurich.

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Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data

TL;DR: P pseudo-transition analysis is introduced, an approach that uses multiple steady-state observations of (13)C-resolved fluxes, metabolites, and transcripts to infer which regulatory events drive metabolic adaptations following environmental transitions, and shows that some dynamic transitions can be approximated as monotonic shifts between steady- state extremes.
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Microbiota-Derived Hydrogen Fuels Salmonella Typhimurium Invasion of the Gut Ecosystem

TL;DR: It is discovered that initial growth of Salmonella Typhimurium in the unperturbed gut is powered by S. Tm hyb hydrogenase, which facilitates consumption of hydrogen, a central intermediate of microbiota metabolism that can be subverted by pathogens and might offer opportunities to prevent infection.
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A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells.

TL;DR: Evidence is presented that the p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding‐protein‐dependent transport systems of Gram‐negative bacteria, and it is suggested that p37 is part a homologous, high‐affinity transport system in M. hyorhinis, a Gram‐positive bacterium.
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The Drosophila melanogaster sex-peptide: A molecular analysis of structure-function relationships

TL;DR: The N-terminal 7 amino acids are not needed for sex-peptide function, whereas the disulfide bridge appears essential, and all results are consistent with the assumption of only one target molecule for both reactions which is accessible via hemolymph.