T
Thorsten Müller
Researcher at Ruhr University Bochum
Publications - 41
Citations - 1371
Thorsten Müller is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Amyloid precursor protein & Neurodegeneration. The author has an hindex of 20, co-authored 40 publications receiving 1200 citations. Previous affiliations of Thorsten Müller include Leibniz Institute for Neurobiology & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease.
TL;DR: A review summarizes recent findings in terms of the origin of AICD by regulated intramembrane proteolysis; its structure, binding factors, and post-translational modifications; and its putative role in gene transcription, apoptosis, and cytoskeletal dynamics.
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Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).
Thorsten Müller,Caoimhín G. Concannon,Manus W. Ward,Ciara M. Walsh,Anca Tirniceriu,Florian Tribl,Donat Kögel,Jochen H. M. Prehn,Rupert Egensperger +8 more
TL;DR: The data point to a role of AICD in developmental and injury-related cytoskeletal dynamics in the nervous system, as well as in A ICD/FE65 transiently transfected murine cortical neurons.
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A Combined Laser Microdissection and Mass Spectrometry Approach Reveals New Disease Relevant Proteins Accumulating in Aggregates of Filaminopathy Patients
Rudolf A. Kley,A. Maerkens,Yvonne Leber,Verena Theis,A. Schreiner,Peter F.M. van der Ven,Julian Uszkoreit,Christian Stephan,Stefan Eulitz,Nicole Euler,Janbernd Kirschner,Klaus Müller,Helmut E. Meyer,Martin Tegenthoff,Dieter O. Fürst,Matthias Vorgerd,Thorsten Müller,Katrin Marcus +17 more
TL;DR: The finding that filamin C was detected as highly abundant protein in aggregates in filaminopathy indicates that the proteomic approach may be suitable to identify new candidate genes among the many MFM patients with so far unknown mutation.
Journal ArticleDOI
Multiple phosphorylations of cytochrome c oxidase and their functions
Stefan Helling,Maik Hüttemann,Rabia Ramzan,Su Hyeon Kim,Icksoo Lee,Thorsten Müller,Elmar Langenfeld,Helmut E. Meyer,Bernhard Kadenbach,Sebastian Vogt,Katrin Marcus +10 more
TL;DR: It is hypothesized that additional phosphorylation(s) may be required for the “allosteric ATP‐inhibition,” and that these sites may be easily dephosphorylated or difficult to identify by mass spectrometry.
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Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy.
A. Maerkens,Rudolf A. Kley,Montse Olivé,Verena Theis,P.F.M. van der Ven,Jens Reimann,Hendrik Milting,A. Schreiner,Julian Uszkoreit,Martin Eisenacher,Katalin Barkovits,Anne-Katrin Güttsches,Jason Tonillo,Katja Kuhlmann,Helmut E. Meyer,Rolf Schröder,Martin Tegenthoff,Dieter O. Fürst,Thorsten Müller,Lev G. Goldfarb,Matthias Vorgerd,Katrin Marcus +21 more
TL;DR: The detection of specific proteomic profiles in different myofibrillar myopathy subtypes indicates that proteomic analysis may become a useful tool in differential diagnosis of protein aggregate myopathies.