R
René-Marc Mège
Researcher at University of Paris
Publications - 110
Citations - 8336
René-Marc Mège is an academic researcher from University of Paris. The author has contributed to research in topics: Cadherin & Cell adhesion. The author has an hindex of 44, co-authored 106 publications receiving 7195 citations. Previous affiliations of René-Marc Mège include Pasteur Institute & Centre national de la recherche scientifique.
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Journal ArticleDOI
E-Cadherin Is the Receptor for Internalin, a Surface Protein Required for Entry of L. monocytogenes into Epithelial Cells
TL;DR: It is reported the first identification of a cellular receptor mediating entry of a gram-positive bacterium into nonphagocytotic cells by an affinity chromatography approach, and reveals a novel type of heterophilic interactions for E-cadherin.
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Mechanobiology of collective cell behaviours.
Benoit Ladoux,René-Marc Mège +1 more
TL;DR: This work has shown that the physical properties of the cellular environment, which include matrix stiffness, topography, geometry and the application of external forces, can alter collective cell behaviours, tissue organization and cell-generated forces.
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Force-dependent conformational switch of α-catenin controls vinculin binding.
Mingxi Yao,Wu Qiu,Ruchuan Liu,Artem K. Efremov,Peiwen Cong,Rima Seddiki,Manon Payre,Chwee Teck Lim,Benoit Ladoux,René-Marc Mège,Jie Yan +10 more
TL;DR: It is demonstrated that physiologically relevant forces reversibly unfurl α-catenin, activating vinculin binding, which then stabilizes α-Catenin in its open conformation, transforming force into a sustainable biochemical signal.
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Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.
René-Marc Mège,Fumio Matsuzaki,Warren J. Gallin,Jeffrey I. Goldberg,Bruce A. Cunningham,Gerald M. Edelman +5 more
TL;DR: These experiments provide support for the precedence hypothesis, which proposes that the linkage of cells by means of CAMs is a necessary event for the extensive expression of junctional structures.
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Regulation of cell-cell junctions by the cytoskeleton.
TL;DR: This work has revealed the important contribution of acto-myosin, microtubules and cell tension to adherens junction formation, cell differentiation and tissue reshaping/remodeling in animal cell-cell adhesion.