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Benjamin P. Kellman
Researcher at University of California, San Diego
Publications - 38
Citations - 2159
Benjamin P. Kellman is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Heparan sulfate & Glycosylation. The author has an hindex of 12, co-authored 33 publications receiving 1158 citations. Previous affiliations of Benjamin P. Kellman include University of California, Los Angeles & University of California.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Journal ArticleDOI
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
Peng Zhao,Jeremy L. Praissman,Oliver C. Grant,Yongfei Cai,Tianshu Xiao,Katelyn E. Rosenbalm,Kazuhiro Aoki,Benjamin P. Kellman,Robert Bridger,Dan H. Barouch,Melinda A. Brindley,Nathan E. Lewis,Nathan E. Lewis,Michael Tiemeyer,Bing Chen,Robert J. Woods,Lance Wells +16 more
TL;DR: Glycomics-informed glycoproteomics is utilized to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of human ACE2, which can facilitate immunogen design to achieve antibody neutralization and inform therapeutic strategies to inhibit viral infection.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,E. M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Gordts, Plsm, Chanda, S. K.,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +34 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain and may represent new therapeutic opportunities for exogenous heparin.
Journal ArticleDOI
A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models.
Sjoerd Opdam,Anne Richelle,Benjamin P. Kellman,Shanzhong Li,Daniel C. Zielinski,Nathan E. Lewis +5 more
TL;DR: To investigate how algorithm and parameter selection affects model content and predictive accuracy, hundreds of models of four different cancer cell lines were built using six algorithms, four gene expression thresholds, and three sets of metabolic constraints.
Journal ArticleDOI
Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants
Chloe A. Autran,Benjamin P. Kellman,Benjamin P. Kellman,Jae H. Kim,Elizabeth Asztalos,Arlin B. Blood,Erin C Hamilton Spence,Aloka L. Patel,Jiayi Hou,Nathan E. Lewis,Nathan E. Lewis,Lars Bode +11 more
TL;DR: DSLNT content in breast milk is a potential non-invasive marker to identify infants at risk of developing NEC, and screen high-risk donor milk, and could serve as a natural template to develop novel therapeutics against this devastating disorder.