T
Tianwei Li
Researcher at National Institutes of Health
Publications - 6
Citations - 348
Tianwei Li is an academic researcher from National Institutes of Health. The author has contributed to research in topics: SUMO protein & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 322 citations.
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Journal ArticleDOI
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: A proteomic analysis
Tianwei Li,Evgenij Evdokimov,Rong-Fong Shen,Chien-Chung Chao,Ephrem Tekle,Tao Wang,Earl R. Stadtman,David C.H. Yang,P B Chock +8 more
TL;DR: Results reveal that several heterogeneous nuclear ribonucleoproteins (hnRNPs), zinc finger proteins, and nuclear pore complex proteins were sumoylated, suggesting that sumoylation could play an important role in regulating mRNA metabolism.
Journal ArticleDOI
Expression of SUMO-2/3 Induced Senescence through p53- and pRB-mediated Pathways
Tianwei Li,Rasa Santockyte,Rong-Fong Shen,Ephrem Tekle,Guanghui Wang,David C.H. Yang,P. Boon Chock +6 more
TL;DR: The results reveal that p53 and pRB can be sumoylated by SUMO-2/3 in vivo, and such modification of p53 or pRB may play roles in premature senescence and stress response.
Journal ArticleDOI
FAT10 modifies p53 and upregulates its transcriptional activity.
Tianwei Li,Rasa Santockyte,Shiqin Yu,Rong-Fong Shen,Ephrem Tekle,Caroline G.L. Lee,David C.H. Yang,P. Boon Chock +7 more
TL;DR: Orexpressing FAT10 led to a reduction in the size of promyelocytic leukemia nuclear bodies (PML-NBs) and altered their distribution in the nucleus and a potential mechanism which correlates FATylation of p53 to its translocation and transcriptional activation is discussed.
Journal ArticleDOI
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
Tianwei Li,Rasa Santockyte,Rong-Fong Shen,Ephrem Tekle,Guanghui Wang,David C.H. Yang,P. Boon Chock +6 more
TL;DR: A general proteomic approach was revealed to elucidate the enzymatic pathways and identify target proteins for three UBLs:sumO-2, SUMO-3, and NEDD8: SUMO/SMO/SOMA, which contain ubiquitin homology domains and can covalently modify target proteins in a manner similar to ubiquitylation.
Journal ArticleDOI
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents
Hoda Zarkoob,Anna Allué-Guardia,Yu-Chi Chen,Andreu Garcia-Vilanova,Olive Jung,Steven L. Coon,Min Jae Song,Jun-Gyu Park,Fatai S. Oladunni,Jesse Miller,YenTing Tung,Ivan Kosik,David C. Schultz,James R. Iben,Tianwei Li,Jiaqi Fu,Forbes D. Porter,Jonathan W. Yewdell,Luis Martinez-Sobrido,Sara Cherry,Jordi B. Torrelles,M Camps Ferrer,Emily M. Lee +22 more
TL;DR: In this paper , the cellular complexity of human alveolar and tracheobronchial air liquid interface (ALI) tissue models during SARS-CoV-2 and influenza A virus (IAV) infections was described.