Fatai S. Oladunni

TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.

TL;DR: A high resolution structure of SARS-CoV-2 nsp16/nsp10 ternary complex in the presence of cognate RNA substrate analogue and methyl donor, S-adenosyl methionine is presented, revealing unique ligand-binding sites that may represent alternative targets for antiviral development.

TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.

TL;DR: This is the first description of a BAC-based reverse genetics system for the generation of infectious rSARS-CoV-2 that displays features in vivo similar to those of a natural viral isolate and will facilitate studies addressing several important questions in the biology of SARS- CoV- 2.

TL;DR: Detailed information on EHV-1 is presented, from the discovery of the virus to latest developments on treatment and control of the diseases it causes, with particular emphasis on viral biology which enables pathogenesis in the natural host.