L
Luis Martinez-Sobrido
Researcher at Texas Biomedical Research Institute
Publications - 287
Citations - 14829
Luis Martinez-Sobrido is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 52, co-authored 226 publications receiving 11478 citations. Previous affiliations of Luis Martinez-Sobrido include University of Rochester Medical Center & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
Yueh Ming Loo,Jamie L. Fornek,Nanette Crochet,Gagan Bajwa,Olivia Perwitasari,Luis Martinez-Sobrido,Shizuo Akira,Michelle A. Gill,Adolfo García-Sastre,Michael G. Katze,Michael Gale +10 more
TL;DR: Differential and redundant roles for RIG-I and MDA5 in pathogen recognition and innate immune signaling that may reflect unique and shared biologic properties of RNA viruses whose differential triggering and control of gene expression may impact pathogenesis and infection are demonstrated.
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Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists
Sarah A. Kopecky-Bromberg,Luis Martinez-Sobrido,Matthew B. Frieman,Ralph A. Baric,Peter Palese +4 more
TL;DR: It has been determined that SARS-CoV open reading frame (ORF) 3b, ORF 6, and N proteins antagonize interferon, a key component of the innate immune response.
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Laura Riva,Shuofeng Yuan,Xin Yin,Laura Martin-Sancho,Naoko Matsunaga,Lars Pache,Sebastian Burgstaller-Muehlbacher,Paul D. De Jesus,Peter Teriete,Mitchell V. Hull,Max W. Chang,Jasper Fuk-Woo Chan,Jianli Cao,Vincent Kwok-Man Poon,Kristina M. Herbert,Kuoyuan Cheng,Kuoyuan Cheng,Tu Trinh H. Nguyen,Andrey Rubanov,Yuan Pu,Courtney Nguyen,Angela Choi,Raveen Rathnasinghe,Michael Schotsaert,Lisa Miorin,Marion Dejosez,Thomas P. Zwaka,Ko Yung Sit,Luis Martinez-Sobrido,Wen-Chun Liu,Kris M. White,Mackenzie E. Chapman,Emma K. Lendy,Richard Glynne,Randy A. Albrecht,Eytan Ruppin,Andrew D. Mesecar,Jeffrey R Johnson,Christopher Benner,Ren Sun,Peter G. Schultz,Andrew I. Su,Adolfo García-Sastre,Arnab K. Chatterjee,Kwok-Yung Yuen,Sumit K. Chanda +45 more
TL;DR: A screen of the ReFRAME library of approximately 12,000 known drugs for antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified several candidate compounds with suitable activities and pharmacological profiles, which could potentially expedite the deployment of therapies for coronav virus disease 2019 (COVID-19).
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Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus
Masaki Mibayashi,Luis Martinez-Sobrido,Yueh Ming Loo,Washington B. Cárdenas,Michael Gale,Adolfo García-Sastre +5 more
TL;DR: The results indicate that, in addition to sequestering dsRNA, the NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3, preventing the transcriptional induction of IFN-β.
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Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
Jorge L. Muñoz-Jordán,Maudry Laurent-Rolle,Joseph Ashour,Luis Martinez-Sobrido,Mundrigi S. Ashok,W. Ian Lipkin,Adolfo García-Sastre +6 more
TL;DR: Deletion analysis shows that that the first 125 amino acids of dengue virus NS4B are sufficient for inhibition of alpha/beta IFN (IFN-α/β) signaling, indicating that proper viral polyprotein processing is required for anti-interferon function.