T
Timo Strünker
Researcher at University of Münster
Publications - 49
Citations - 2574
Timo Strünker is an academic researcher from University of Münster. The author has contributed to research in topics: Sperm & Sperm motility. The author has an hindex of 20, co-authored 42 publications receiving 2134 citations. Previous affiliations of Timo Strünker include Max Planck Society & Forschungszentrum Jülich.
Papers
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Book ChapterDOI
Kinetic and photonic techniques to study chemotactic signaling in sea urchin sperm.
Hussein Hamzeh,Luis Alvarez,Timo Strünker,Michelina Kierzek,Christoph Brenker,Parker E. Deal,Evan W. Miller,Reinhard Seifert,U. Benjamin Kaupp +8 more
TL;DR: The signaling pathway and molecular components endowing sperm with single-molecule sensitivity are described and the techniques and chemical tools used to resolve the signaling events in time are described.
Journal ArticleDOI
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm.
Rita Rahban,Rita Rahban,Anders Rehfeld,Christian Schiffer,Christoph Brenker,Dorte Louise Egeberg Palme,Tao Wang,Tao Wang,Johannes Lorenz,Kristian Almstrup,Niels E. Skakkebæk,Timo Strünker,Serge Nef,Serge Nef +13 more
TL;DR: In this paper, the SSRI antidepressant Sertraline (e.g., Zoloft) was selected for in-depth analysis of its action on steroid-, prostaglandin-, pH- and voltage-activation of human CatSper.
Journal ArticleDOI
The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm.
Janice K. Jeschke,Cristina Biagioni,Tobias Schierling,Isabel Viola Wagner,Isabel Viola Wagner,Frederik Börgel,Dirk Schepmann,Andreas N. Schüring,Alexandra Kulle,Paul Martin Holterhus,Michael von Wolff,Bernhard Wünsch,Verena Nordhoff,Timo Strünker,Christoph Brenker +14 more
TL;DR: In this paper, the action of seminal and follicular fluid as well as the contained individual prostaglandins and steroids on the intracellular Ca2+ concentration of sperm from donors and CATSPER2-deficient patients that lack functional CatSper channels was studied.
Journal ArticleDOI
4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region.
Eva Bollmann,Julian A. Schreiber,Nadine Ritter,Stefan Peischard,Huyen Tran Ho,Bernhard Wünsch,Timo Strünker,Sven G. Meuth,Thomas Budde,Nathalie Strutz-Seebohm,Guiscard Seebohm +10 more
TL;DR: It is shown that the central S6 region serves as a hub for allosteric channel activation by the drug and that DIDS shortens the pseudo QT interval in iPSC cardiomyocytes.
Posted ContentDOI
Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling
Tao Wang,Tao Wang,Samuel M. Young,Frank Tüttelmann,Albrecht Röpke,Claudia Krallmann,Sabine Kliesch,Xu-Hui Zeng,Christoph Brenker,Timo Strünker +9 more
TL;DR: The concept of an intracellular cAMP/PKA-activation of CatSper is primarily based on unspecific effects of chemical probes used to interfere with cAMP signaling, and these findings solve several controversial issues and have important bearings on future studies of cAMP and Ca2+ signaling and the ligand-control ofCatSper in sperm.