S
Sven G. Meuth
Researcher at University of Münster
Publications - 522
Citations - 13780
Sven G. Meuth is an academic researcher from University of Münster. The author has contributed to research in topics: Medicine & Multiple sclerosis. The author has an hindex of 57, co-authored 412 publications receiving 10334 citations. Previous affiliations of Sven G. Meuth include University of Würzburg & Otto-von-Guericke University Magdeburg.
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Journal ArticleDOI
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
Christoph Kleinschnitz,Henrike Grund,Kirstin Wingler,Melanie E. Armitage,Emma S Jones,Manish Mittal,David Barit,Tobias Schwarz,Christian Geis,Peter Kraft,K. Barthel,Michael K. Schuhmann,Alexander M. Herrmann,Sven G. Meuth,Guido Stoll,Sabine Meurer,Anja Schrewe,Lore Becker,Valerie Gailus-Durner,Helmut Fuchs,Thomas Klopstock,Martin Hrabé de Angelis,Karin Jandeleit-Dahm,Ajay M. Shah,Norbert Weissmann,Harald H.H.W. Schmidt +25 more
TL;DR: The identification of NOx4 as a major source of oxidative stress in stroke and demonstration of dramatic protection after stroke in mice by NOX4 deletion or NOX inhibition, opens up new avenues for treatment.
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Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
Christoph Kleinschnitz,Peter Kraft,Angela Dreykluft,Ina Hagedorn,Kerstin Göbel,Michael K. Schuhmann,Friederike Langhauser,Xavier Helluy,Tobias Schwarz,Stefan Bittner,Christian T. Mayer,Marc Brede,Csanad Varallyay,Mirko Pham,Martin Bendszus,Peter M. Jakob,Tim Magnus,Sven G. Meuth,Yoichiro Iwakura,Alma Zernecke,Tim Sparwasser,Bernhard Nieswandt,Guido Stoll,Heinz Wiendl +23 more
TL;DR: A novel and unexpected role of Tregs in a primary nonimmunologic disease state is defined, which reduced microvascular thrombus formation and improved cerebral reperfusion on stroke, as revealed by ultra-high-field magnetic resonance imaging at 17.6 Tesla.
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STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Alejandro Berna-Erro,Attila Braun,Robert Kraft,Christoph Kleinschnitz,Michael K. Schuhmann,David Stegner,Thomas Wultsch,Jens Eilers,Sven G. Meuth,Guido Stoll,Bernhard Nieswandt +10 more
TL;DR: It is shown that STIM2, but not STIM1, is essential for CCE and ischemia-induced cytosolic Ca2+ accumulation in neurons, which implicate CCE in ischemic neuronal cell death and establishSTIM2 as a critical mediator of this process.
Journal ArticleDOI
Calcium-dependent inactivation of neuronal calcium channels
TL;DR: A structural understanding of this mechanism will provide a framework for understanding the regulation of Ca2+ entry and accumulation in neurons.
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
David Schafflick,Chenling Xu,Maike Hartlehnert,Michael Cole,Andreas Schulte-Mecklenbeck,Tobias Lautwein,Jolien Wolbert,Michael Heming,Sven G. Meuth,Tanja Kuhlmann,Catharina C. Gross,Heinz Wiendl,Nir Yosef,Nir Yosef,Gerd Meyer zu Hörste +14 more
TL;DR: A single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis patients is provided, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.