T
Timothy J. Davies
Researcher at University of Oxford
Publications - 22
Citations - 2522
Timothy J. Davies is an academic researcher from University of Oxford. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 12, co-authored 22 publications receiving 2333 citations. Previous affiliations of Timothy J. Davies include National Institute for Health Research.
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Journal ArticleDOI
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Paul J. Tesar,Josh G. Chenoweth,F. A. Brook,Timothy J. Davies,Edward P. Evans,David L. Mack,Richard L. Gardner,Ronald D.G. McKay +7 more
TL;DR: It is shown that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper, and interrogated to understand how pluripotent cells generate distinct fates during early development.
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Human induced pluripotent stem cells are capable of B-cell lymphopoiesis
Lee Carpenter,R. K. Malladi,Cheng-Tao Yang,Anna French,Anna French,Katherine J. Pilkington,Richard W. Forsey,Jackie Sloane-Stanley,Kathryn M. Silk,Timothy J. Davies,Paul J. Fairchild,Tariq Enver,Suzanne M. Watt +12 more
TL;DR: It is demonstrated, for the first time, that human iPS cells are able to undergo hematopoiesis that contributes to the B-cell lymphoid lineage.
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Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141 + XCR1 + dendritic cells
Kathryn M. Silk,J D Silk,N Ichiryu,Timothy J. Davies,Kathleen F. Nolan,Alison J. Leishman,Lee Carpenter,Lee Carpenter,Suzanne M. Watt,Suzanne M. Watt,Vincenzo Cerundolo,Paul J. Fairchild +11 more
TL;DR: The ability to generate a potentially unlimited source from iPS cells offers the possibility of harnessing their capacity for cross-priming of cytotoxic T lymphocytes for the induction of tumour-specific immune responses.
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Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset.
TL;DR: Protocols for the directed differentiation of human iPSCs into a mixed population of CD11c+ DCs are described, providing access to a novel source of DCs analogous to the CD141+ subset under steady-state conditions in vivo and may find utility in the treatment of a range of disease states requiring the establishment of immunological tolerance.
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The basis and significance of pre-patterning in mammals.
TL;DR: The second polar body (Pb) provides an enduring marker of the animal pole of the zygote, thereby revealing that the axis of bilateral symmetry of the early blastocyst is aligned with theZygote's animal-vegetal axis.