T
Timothy J. Wright
Researcher at Merck & Co.
Publications - 11
Citations - 174
Timothy J. Wright is an academic researcher from Merck & Co.. The author has contributed to research in topics: Anacetrapib & CETP inhibitor. The author has an hindex of 3, co-authored 11 publications receiving 133 citations.
Papers
More filters
Journal ArticleDOI
Reaction development and mechanistic study of a ruthenium catalyzed intramolecular asymmetric reductive amination en route to the dual Orexin inhibitor Suvorexant (MK-4305).
Neil A. Strotman,Carl A. Baxter,Karel M. J. Brands,Ed Cleator,Shane W. Krska,Robert A. Reamer,Debra J. Wallace,Timothy J. Wright +7 more
TL;DR: The first example of an intramolecular asymmetric reductive amination of a dialkyl ketone with an aliphatic amine has been developed for the synthesis of Suvorexant (MK-4305), a potent dual Orexin antagonist under development for the treatment of sleep disorders.
Patent
Process for the preparation of an orexin receptor antagonist
Carl A. Baxter,Edward Cleartor,Shane W. Krska,Faye J. Sheen,Gavin W. Stewart,Neil A. Strotman,Debra J. Wallace,Timothy J. Wright +7 more
TL;DR: In this article, a diazepane compound which is an antagonist of orexin receptors is presented, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which oxin receptors are involved.
Journal ArticleDOI
Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods
Artis Klapars,John Y. L. Chung,John Limanto,Ralph Calabria,Louis-Charles Campeau,Kevin R. Campos,Wenyong Chen,Stephen M. Dalby,Tyler A. Davis,Daniel A. DiRocco,Alan M. Hyde,Amude M. Kassim,Mona Utne Larsen,Guiquan Liu,Peter E. Maligres,Aaron Moment,Feng Peng,Rebecca T. Ruck,Michael Shevlin,Bryon Simmons,Zhiguo Jake Song,Lushi Tan,Timothy J. Wright,Susan L. Zultanski +23 more
TL;DR: In this article, an efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield, achieved by development of several synthetic methods: (1) complexation-driven selective acyl migration/oxidation; (2) BSA-mediated cyclization to anhydrouridine; (3) hydrochlorination using FeCl3/TMDSO; (4) dynamic stereoselective phosphoramidation using a chiral nucleophilic catalyst.
Journal ArticleDOI
Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction
Michael Pirnot,Kevin H. Stone,Timothy J. Wright,David J. Lamberto,Jochen Schoell,Yu-hong Lam,Kerstin Zawatzky,Xiao Wang,Stephen M. Dalby,Adam J. Fine,Jonathan P. McMullen +10 more
Journal ArticleDOI
Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation
John Y. L. Chung,Amude M. Kassim,Bryon Simmons,Tyler A. Davis,Zhiguo J. Song,John Limanto,Stephen M. Dalby,Cyndi Qixin He,Ralph Calabria,Timothy J. Wright,Louis-Charles Campeau +10 more