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Xiao Wang
Researcher at Merck & Co.
Publications - 62
Citations - 966
Xiao Wang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 15, co-authored 51 publications receiving 616 citations. Previous affiliations of Xiao Wang include Peking University & University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.
Qirui Guo,Yingchi Zhao,Junhong Li,Jiangning Liu,Xiu-hong Yang,Xuefei Guo,Ming Kuang,Huawei Xia,Zeming Zhang,Lili Cao,Yujie Luo,Linlin Bao,Xiao Wang,Xuemei Wei,Wei Deng,Nan Wang,Luoying Chen,Jingxuan Chen,Hua Zhu,Ran Gao,Chuan Qin,Xiangxi Wang,Fuping You +22 more
TL;DR: In this paper, the authors characterized the transcriptome of rhesus macaques and mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis.
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Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence
Zhiqiang Ma,Xiaolei Wang,Xiao Wang,Rodrigo A. Rodriguez,Curtis E. Moore,Shuanhu Gao,Xianghui Tan,Yuyong Ma,Arnold L. Rheingold,Phil S. Baran,Chuo Chen +10 more
TL;DR: Through de novo synthesis of sceptrin and massadine, it is shown that sponges may use single-electron oxidation as a central mechanism to promote three different types of cycloaddition and reveals enantiodivergence as a new biosynthetic paradigm for natural products.
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Dimeric pyrrole–imidazole alkaloids: synthetic approaches and biosynthetic hypotheses
TL;DR: The pyrrole-imidazole alkaloids are a group of structurally unique and biologically interesting marine sponge metabolites that have caught synthetic chemists' attention particularly.
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Asymmetric synthesis of ageliferin
TL;DR: An asymmetric synthesis of ageliferin is described, using a Mn(III)-mediated oxidative radical cyclization reaction as the key step to construct the core skeleton of this pyrrole-imidazole dimer.
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Investigating the Underappreciated Hydrolytic Instability of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous Bases
TL;DR: The widespread use of amidine and guanidine bases in synthetic chemistry merits a thorough understanding of their chemical properties and the propensity of these reagents to hydrolyze under mild condi....