J
John Y. L. Chung
Researcher at Merck & Co.
Publications - 89
Citations - 1310
John Y. L. Chung is an academic researcher from Merck & Co.. The author has contributed to research in topics: Enantioselective synthesis & Lactam. The author has an hindex of 22, co-authored 89 publications receiving 1193 citations.
Papers
More filters
Journal ArticleDOI
Conformationally constrained amino acids. Synthesis and optical resolution of 3-substituted proline derivatives
John Y. L. Chung,James T. Wasicak,William A. Arnold,Catherine S. May,Alex M. Nadzan,Mark W. Holladay +5 more
TL;DR: The modification apportee dans la synthese de prolines substituees en 3 consiste en l'utilisation de triethyl silane and d'acide trifluoro acetique for the reduction des pyrrolidine dicarboxylates-2,2 initiaux, and en la protection du N des prolines par le t-butoxycarbonyl; les racemiques obtenus sont ensuite dedoubles as mentioned in this paper.
Journal ArticleDOI
Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling.
Mark S. Jensen,Chunhua Yang,Yi Hsiao,Nelo R. Rivera,Kenneth M. Wells,John Y. L. Chung,Nobuyoshi Yasuda,David L. Hughes,Paul J. Reider +8 more
TL;DR: A short synthesis of carbapenem 1 is described, which involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon and utilizes a stannatrane as the heteroalkyl transfer reagent.
Patent
Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
Ian Mangion,Mark A. Huffman,Rebecca T. Ruck,Joseph J. Lynch,John Y. L. Chung,Benjamin Marcune +5 more
TL;DR: A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III is described in this article.
Journal ArticleDOI
Diastereoselective Friedel−Crafts Alkylation of Indoles with Chiral α-Phenyl Benzylic Cations. Asymmetric Synthesis of Anti-1,1,2-Triarylalkanes
John Y. L. Chung,Danny Mancheno,Peter G. Dormer,Narayan Variankaval,Richard G. Ball,Nancy N. Tsou +5 more
TL;DR: The reactions of chiral benzyl carbocations bearing alpha-phenyl substituents with N-sulfonylated indoles afford 1,1,2-triarylalkanes with anti-selectivities, providing an efficient access to sterically congested tetrasubstituted ethanes.
Journal ArticleDOI
A General Procedure for the Preparation of β-Ketophosphonates
TL;DR: A mild, high-yielding procedure for the preparation of beta-ketophosphonates is described, which is operationally simple and amenable to large-scale preparations.