Timothy K. Y. Kaan

TL;DR: A critical role is suggested for the P2X7 receptor in the enhanced nociceptive transmission associated with microglial activation and secretion of IL-1β in the dorsal horn and it is suggested that CNS-penetrant P2x7 receptor antagonists, by targeting microglia in pain-enhanced response states, may be beneficial for the treatment of persistent pain.

TL;DR: Test the hypothesis that adenosine triphosphate is one such key mediator through actions on P2X3 and P2 X2/3 receptors, which are expressed selectively on primary afferent nocioceptors, including those innervating the bone to suggest that systemic P2x3 andP2X2/ 3 receptor antagonists with central nervous system penetration may offer a promising therapeutic tool in treating bone cancer pain.

TL;DR: A clear correlation of the UVB response in rat and in human skin was shown, giving the authors confidence that their rat results would apply in humans, as well as proof that a neutralizing antibody to the chemokine protected against the pain and infiltration of immune cells.

TL;DR: It is shown that brain-derived neurotrophic factor and NT-3, but not nerve growth factor or neurotrophin-4, are upregulated in the spinal gray matter after DRI, illustrating a novel, plasticity-suppressing effect of endogenous TrkB ligands on mechanosensation and mechanosensory primary afferent axons after spinal deafferentation.

TL;DR: The protocol in this study provides rapid isolation of microglia from adult spinal cord, allowing immediate availability for experimentation of both ex vivo and in vitro within a few hours, with a purity of 99% with little or no neuronal or astrocytic contamination.